Tag Archives: life

Dr. M’s Women and Children First Podcast #59 – Randy Jirtle, Ph. D. – The Imprintome and Hope

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Randy Jirtle, Ph.D.
This week’s guest is Professor Randy Jirtle.
Dr. Randy Jirtle joins the show for the second time today to discuss his new research on the imprintome, the regulatory regions that at the earliest stages of fetal development control our epigentic and thus our genetic outcome. This is the Hope locus.
Time Magazine nominated him for person of the year in 2007 and had this to say about him: “Dr. Jirtle’s pioneering work in epigenetics and genomic imprinting has uncovered a vast territory in which a gene represents less of an inexorable sentence and more of an access point for the environment to modify the genome. His trailblazing discoveries have produced a far more complete and useful understanding of human development and diseases” — Time Magazine. This interview is ground zero for the Women and Children First Podcast as we discuss the underpinnings or mechanisms of disease risk for all humans as it relates to the environmental inputs of our lives that are driving health or disease at both the pregnancy and post natal periods. We look specifically at how maternal nutrition and later chemical exposure directly affected the health of the agouti mouse offspring. This experiment was the first of its kind and paved the way for a complete shift in human disease understanding. For parents, this podcast is really the beginning of everything that I am trying to convey regarding a healthy pregnancy and childhood. Without this interview, the following interviews will be more difficult to understand. The picture becomes very clear once his research is cemented in our minds.
His biography is as follows: Professor of Epigenetics at the Department of Biological Sciences, North Carolina State University, Raleigh, NC, and a Senior Scientist at McArdle Laboratory for Cancer Research at the University of Wisconsin, Madison, WI. He was previously professor of radiation oncology and associate professor of pathology at Duke University, Durham, NC, where he had been a faculty member since 1977. He graduated with a B.S. degree in nuclear engineering in 1970 and a Ph.D. degree in radiation biology in 1976, from the University of Wisconsin-Madison. His awards list is long but the key to Dr. Jirtle is that he is a curious thinker and we are grateful for this.
Please enjoy my conversation with Dr. Randy Jirtle,
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 20

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Section I – An Uncivilized Journey Part II
(Being Vulnerable part II)
I continued my wandering journey of self discovery this year. Finding myself back in rural Austin, Texas, there would be no preconceived idea for me what this stop on the path would uncover and offer me in witness and self emotional understanding. Not to disappoint, this journey was easily 5X more mind and heart opening than last April. The past year has been tumultuous for me as you all may remember. I am still coming off the reality of losing my rock in the world, my father. It is a strange feeling. The knowing that he is gone and that I must live without his counsel, love and support. But, live we all must with loss, grief and existence…..
Best,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 40

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Dr. Katz – “Human offspring come into this world much like the young of all other mammals, and like all the others, within minutes of our arrival, we are hungry. Food figures prominently in our lives ever after, but never is it more important than in childhood, when it serves as the literal construction material of those growing bodies and brains. The initial food choice for human babies should be self-evident, as it is for all other baby mammals: the milk of their mothers. The provision of that milk is among the defining characteristics of the mammalian class; it is part of what makes us what we are….

Also, we discuss marijuana and vaping as well as new work by Derek Sivers.

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #21 – Traver Boehm – An Uncivilized Journey

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What does it mean to be a man in modern times? To be in tune with and feel all aspects of one’s life experiences? To be unapologetic, authentic and safe? To move past trauma and pain? In other words, to be a man uncivilized.
To better understand these questions, I give you the words or Traver Boehm: “Men had to choose between two outdated and broken options….Be the Lone Wolf and die ALONE with a chest full of unexpressed emotions and a wake of broken relationships behind him. A man who thinks the feminine is weakness and weakness is unbearable. He misunderstands that within his weaknesses lie his greatest strengths. Or… Be the Sensitive New Age “Nice Guy” and have a million bestest girlfriends, now living as the wolf in sheep’s clothing. A man who thinks the masculine is terrifying and is forced to deny every aspect of his own manhood. If you are a “Nice Guy”— you are living someone else’s life. But the truth wasn’t in these two options, was it? I knew it. Most men knew it. We just couldn’t find it. And until you have your own back, you can’t truly have anybody else’s. WHAT IF THERE WAS AN OPTION FOR MEN TO BREAK OUT OF THEIR CAGED LIVES AND BECOME FREE?
A Good Man, a Strong Man, a WHOLE MAN.”
This podcast is an exploration of Traver and his thoughts on these topics. He is a man on a mission to help men become better men. He is a thinker, podcaster, writer and so much more.
Enjoy my conversation with Traver Boehm,
Dr. M

Dr. M’s Women and Children First Podcast #14 – Dr. Richard Johnson, Nature Wants Us To Be Fat

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Richard J. Johnson, M.D. is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will introduce you to the exceptional work of Dr. Johnson and how we are now mismatched metabolically for the environment of modern America and our food systems.

Please enjoy this wide ranging conversation.

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 11 Issue 52 and Volume 12 Issue 2

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11 Years Gone by!
What have we learned in 2021?
1) Covid is truly remarkable and also a major pain in the …. Messaging and political policies have been mostly dysfunctional and persist in many places today. The vaccine effort has been nothing less than heroic and saved countless lives. Media companies and the CDC continue to avoid the elephant in the room, poor quality nutrition, obesity and metabolic self induced derangements. Life continues for most of us while we mourn the loss of those that have succumbed to COVID. Getting significant COVID illness portends high death risk acutely and during the first year after recovery by a significant margin. Vaccination for high risk groups is the only chance of reducing this risk. See this mortality Graph (Manious et. al. 2021)
Lymphatics
Lymphatics – a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease.
Enjoy,
Dr. M
For the written newsletter visit: https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter

Dr. M’s SPA Newsletter Audiocast Volume 11 Issues 33 and 35 Covid Update #41/42

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A few people are asking about the need to vaccinate if you have already had COVID natural illness. What is the story here? Hot off of the press from Cell Reports Medicine, we see: “Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. Here, we evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based immune responses. SARS-CoV-2 spike binding and neutralizing antibodies exhibit a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells. SARS-CoV-2 infection also boosts antibody titers to SARS-CoV-1 and common betacoronaviruses. In addition, spike-specific IgG+ memory B cells persist, which bodes well for a rapid antibody response upon virus re-exposure or vaccination. Virus-specific CD4+ and CD8+ T cells are polyfunctional and maintained with an estimated half-life of 200 days. Interestingly, CD4+ T cell responses equally target several SARS-CoV-2 proteins, whereas the CD8+ T cell responses preferentially target the nucleoprotein, highlighting the potential importance of including the nucleoprotein in future vaccines. Taken together, these results suggest that broad and effective immunity may persist long-term in recovered COVID-19 patients.” (Cohen et. al. 2021)

Read more for COVID #41……https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/988-volume-11-letter-33-coronavirus-update-42

Read more for COVID #42……https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/994-coronavirus-update-42

Happy listening

Dr. M