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Please Enjoy,
Dr. M
Podcast: Play in new window | Download
Please Enjoy,
Dr. M
Podcast: Play in new window | Download
Today, we are honored to have Dr. E. John Wherry, a leading expert in the field of immunology, joining us. Dr. Wherry is the Chair of the Department of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania, where he also directs the Institute for Immunology. His undergraduate degree was obtained at Penn State University before completing his PhD in Immunology at the Thomas Jefferson University.
A thought leader in T cell biology and immune memory, Dr. Wherry’s work has been instrumental in improving therapies for viral infections, vaccines, and immunotherapy treatments. His discoveries in the field of immune exhaustion have had a profound impact on the way we approach treatments for cancer and autoimmune diseases. Widely published in top academic journals including Nature, Cell, and Science, Dr. Wherry is a heavy contributor to Covid research and especially the understandings of long Covid.
Today, we discuss Covid and the current state of the science regarding vaccines, long covid and what we can do better next time there is a pandemic.
Enjoy,
Dr. M
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Section I
Literature Review
1) Long Covid in children – the symptoms are getting more clarity in who has what . From JAMA: 898 school-age children (751 with previous SARS-CoV-2 infection and 147 without) and 4469 adolescents (3109 infected and 1360 uninfected) were included in the analysis. The time between infection and symptom analysis was 1.5 years. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. The cumulative data shows us that neurocognitive (Headache, attention concerns, sleep dysregulation), pain, and gastrointestinal symptoms in school-age children were common, but changed to loss of smell and/or taste, body aches and pain, focus struggles and fatigue related symptoms in adolescents. (Gross et. al. 2024) Age has a huge effect on these outcomes as the older population has more frequent and problematical disease findings. Mood disorder is highly associated with worsened findings. I suspect from the historical data set over the last four years that children with chronic mental stress, poor quality diets, sleep issues, and poor activity levels at baseline have worsened acute and long term prognosis.
Plus a section on a book review for Change Your Genes, Change Your Life.
Enjoy,
Dr. M
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Coronavirus Update #65
This week we take another and deeper dive into PACS or long covid. What are the risk factors for it? How does the intestinal microbiome play out in this space? Are there certain bacteria that are associated with a negative outcome? Can we alter them to our advantage? We also take a closer look at the current variants of the Omicron lineage. Finally, we end with a discussion of social media concerns.
Enjoy,
Dr. M
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Dr. Peter Rowe is a Professor of Pediatrics at the Johns Hopkins University School of Medicine. He is the inaugural Sunshine Natural Wellbeing Foundation Professor of Chronic Fatigue and Related Disorders and serves as the Director of the Chronic Fatigue Clinic at Johns Hopkins Children’s Center.
His areas of clinical expertise include chronic fatigue syndrome and other disorders characterized by fatigue and orthostatic intolerance. Dr. Rowe and his colleagues were the first to describe the relationship between chronic fatigue syndrome (CFS) and treatable orthostatic intolerance syndromes, as well as the association between Ehlers-Danlos syndrome and CFS.
In this episode, Dr. Rowe and I dive deep into CFS and long Covid for both the parent and the clinician. We set the stage for a better understanding of this complex disorder in order to encourage earlier diagnosis and better therapy.
Please Enjoy,
Dr. M
Majestic poplar
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Newsletter #32 covers – School and the Covid Generation
Newsletter #34 covers – Long Covid and its association with Epstein Barr Virus, EBV, reactivation