Tag Archives: immunity

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 36

Biome Depletion Theory or Biota Alteration Theory
When we look at risk of disease over time in humans, we need to take stock in what was supposed to be versus what is. If we become mismatched genetically to the environment that we find ourselves in, then we will begin to suffer disease. The work of Dr. William Parker and colleagues is very fascinating here. His understanding of our immune solvency takes us back to a time when macrobes like parasites lived with us in a semi-symbiotic way. Most of them were harmless where a few were pathogenic. This matters tremendously because as we are learning, the microbes that exist within us play a major role in tuning the immune system towards tolerance and effective pathogen killing.
A lot to explore here,
Dr. M

Dr. M’s Women and Children First Podcast #16 – Dr. George Munoz – Covid Risk and Prevention

Podcast #16 – Dr. George Munoz – Covid Risk and Prevention

Dr. George Munoz is a board certified Rheumatologist with over 30 years of experience with complex immune related disorders. He obtained his undergraduate degree from Columbia before heading to Mount Sinai School of Medicine for his medical degree. He pursued a Rheumatology fellowship at Harvard before we crossed paths during our Fellowship in Integrative medicine at the University of Arizona Center for Integrative Medicine.  George is a thinker and a gentleman whose mission has been to change the lives of individuals suffering from Rheumatologic disease.

As Covid has been omnipresent in our lives, we decided to sit down and discuss the underlying risk factors of Covid disease and what can be done to reduce future risk. It is a wide ranging conversation that covers the gamut of lifestyle related factors predisposing us to disease.

 

I hope that enjoy my conversation with Dr. George Munoz,

Dr. M

Dr. M’s Women and Children First Podcast #7 – Dr. William Parker, The “Macrobiome” and Human Health

Dr. William Parker, Associate Professor of Surgery and Global Health at Duke University, will discuss the biome depletion theory and how our cleanliness is disrupting normal immune function. These processes can have profound downstream effects on maternal and child health. From the Duke Medical School: What is widely known as the “hygiene hypothesis” is more appropriately described as the biota alteration or biome depletion theory: Changes in symbiont composition in the ecosystem of the human body in Western culture has led to immune dysfunction and subsequent disease. We are working on several aspects of this theory. Our earlier studies probe the immunological differences between laboratory-raised and wild-raised animals as a means of assessing differences between humans with and without Western culture, respectively. Other studies probe the role of biome enrichment, in particular the addition of helminths, in the treatment of disease. Studies are ongoing in both humans and in animals, with particular attention to the role of biome depletion in cognitive dysfunction.

We discuss the future of human health with a specific focus on our macrobiome friends, parasites, with whom we have co evolved. They are now missing and we are not better off because of it.

 

Please enjoy my conversation with Dr. William Parker,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 11 Issues 32 and 34

Majestic poplar

Newsletter #32 covers – School and the Covid Generation

More than a year later, as we had feared, we are starting to see and feel the repercussions of the school closure pandemic phenomenon. The K shaped recovery of the economic pandemic is also playing out similarly in the school system. Last year, private schools stayed open while public schools shuttered. Of those in public school systems, many that could afford one, hired tutors to bridge the academic dysfunction of zoom education. The gap between the rich and poor just widened like never before right before our eyes. Regardless of the intent behind the outcome, we are now here. It serves no purpose to blame teachers unions or local governments or parents living in fear or any other publicized reason to date. We are Americans and we must now roll up our sleeves and begin the process of bridging this gap again. These children deserve our total and unwavering support. Link to more….https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/983-school-and-the-covid-generation

Newsletter #34 covers – Long Covid and its association with Epstein Barr Virus, EBV, reactivation

This is a very important topic for clinicians and parents to understand so we are going to look at it a little more deeply.
Long COVID or what appears to be a post infectious inflammatory issue may now be a consequence of another infection. What are the symptoms of long COVID and when do they occur? From the CDC: Some people are experiencing a range of new or ongoing symptoms that can last weeks or months after first being infected with the virus that causes COVID-19. Unlike some of the other types of post-COVID conditions that only tend to occur in people who have had severe illness, these symptoms can happen to anyone who has had COVID-19, even if the illness was mild, or if they had no initial symptoms. Symptoms can even begin weeks after the infection.  Link to more…. https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/990-long-covid-and-its-association-with-epstein-barr-virus-ebv-reactivation

Dr. M’s SPA Newsletter Volume 11 Issue 31 Covid Update #40

It is time for a change of direction for me and my vaccine thoughts. A lot of risk analysis this week in children and opinions on masking to be in schools. I have been steadfastly in the push to vaccinate high risk kids over age 12 years only and all else make individual choices. The data keeps shifting and the risk of a potential concern is increasing for adolescents. Read on….
Quick hits
1) COVID mRNA vaccines for 12 and over – a few days ago, I had the pleasure of interviewing Dr. Danny Benjamin, Professor of Pediatric Infectious Diseases at Duke University and Principal Investigator on the NC school COVID study, about the COVID vaccine, variants and risk factors for problems in children. He is a brilliant and thoughtful teacher and someone that I truly trust. Our interview will be live in 1 – 2 weeks at the Women and Children First Podcast on Apple podcasts. However, there was one HUGE takeaway that I wanted to share now.
According to Dr. Benjamin, the COVID vaccine has already surpassed the necessary amount of time and number of inoculated children over 12 years of age to steadfastly discuss safety as a net known entity. In the history of vaccine development, there has never been a case of a new unknown side effect being discovered 6 months post any individual vaccination if enough people have been vaccinated to see a signal….. Read More Here: https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/977-volume-11-letter-31-coronavirus-update-40

From the desk of Doc Smo: Whooping Cough Update (article)

 

Public attention has been intensifying over concern that we are losing the war against a severe disease called whooping cough: a disease that we thought we had licked back in the 70’s. This highly infectious bacterial infection, that attacks a child’s bronchi, is making a major resurgence in the US.   Currently Washington State and California have gotten the brunt of what is now being called an epidemic.  In 2010 alone, 27,550 cases of whooping cough were reported in the US.

 

Here is the scary part of the evolving whooping story.  While being properly vaccinated reduces a child’s chances of getting infected by 8 fold, the majority of the cases of that have occurred in California and Washington state have been among young infants who have not completed their initial vaccines and among older children. What is particularly alarming to experts is that most of the cases in older children have afflicted ADEQUATELY VACCINATED CHILDREN clustering in the 7-10 year olds and the 13-14 year olds. In other words, the vaccine does not seem to be working since properly immunized children are coming down with the illness!

 

To understand this further, you need to know a little bit of the history of the vaccine.  Up until the 90’s, pertussis vaccine was made from the “whole cell” of the germ borditella pertussis. The vaccine worked very well but created a lot of side effects such as high fever and large swellings at the site of the shot.  In the “old days” of the whole cell DPT, we never gave the 18 month or 4-6 year booster in the legs because so many parents complained that they had to carry their children around for a few days if we gave it in their child’s leg!  We also didn’t give this vaccine to anyone over 6 years of age because they just couldn’t tolerate it.  Then came the acellular version of the DPT, also known as DPaT (the “a” standing for acellular).  This is the version of pertussis vaccine that we are using today that seems not to be giving very longstanding immunity. It just doesn’t work as well as the old whole cell version.

 

So the choice now seems clear.  Either we immunize everyone with more frequent doses of the modern acellular pertussis vaccine or we go back to the good old days with the whole cell vaccine and put up with the high fevers and large swellings. It will be interesting to see what the experts decide to do. Stay tuned and get ready to roll up your sleeves, I have a felling more shots are coming your way.

 

Smo Notes:

 

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6128a1.htm?s_cid=mm6128a1_e