Tag Archives: hygiene hypothesis

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 36

Biome Depletion Theory or Biota Alteration Theory
When we look at risk of disease over time in humans, we need to take stock in what was supposed to be versus what is. If we become mismatched genetically to the environment that we find ourselves in, then we will begin to suffer disease. The work of Dr. William Parker and colleagues is very fascinating here. His understanding of our immune solvency takes us back to a time when macrobes like parasites lived with us in a semi-symbiotic way. Most of them were harmless where a few were pathogenic. This matters tremendously because as we are learning, the microbes that exist within us play a major role in tuning the immune system towards tolerance and effective pathogen killing.
A lot to explore here,
Dr. M

Dr. M’s Women and Children First Podcast #9 – Dr. Tracy Shafizadeh, Evivo Probiotic for Babies

Dr. Tracy Shafizadeh is a nutritional scientist, speaker, and author with over 15 years of experience in scientific communications and life science research. Prior to serving as the Director of Scientific Communications at Evolve BioSystems, she led both product development and research services at various start-up life science companies, including Lipomics Technologies, Tethys Bioscience and Metabolon, Inc. Dr. Shafizadeh received her PhD in nutritional biology from UC Davis, studying intestinal development and folate metabolism in newborns.

Today, we spend the hour discussing the maternal and infant microbiome with respect to maternal breastmilk, human milk sugars and childhood outcome. Evolve Biosystems has produced a probiotic with excellent science to help guide us in new therapeutic discovery. We head to the beginnings of disease onset when the infant is only starting to take his or her first breaths.

I hope that you enjoy my conversation with Dr. Tracy Shafizadeh,

Dr. M

 

Dr. M’s Women and Children First Podcast #7 – Dr. William Parker, The “Macrobiome” and Human Health

Dr. William Parker, Associate Professor of Surgery and Global Health at Duke University, will discuss the biome depletion theory and how our cleanliness is disrupting normal immune function. These processes can have profound downstream effects on maternal and child health. From the Duke Medical School: What is widely known as the “hygiene hypothesis” is more appropriately described as the biota alteration or biome depletion theory: Changes in symbiont composition in the ecosystem of the human body in Western culture has led to immune dysfunction and subsequent disease. We are working on several aspects of this theory. Our earlier studies probe the immunological differences between laboratory-raised and wild-raised animals as a means of assessing differences between humans with and without Western culture, respectively. Other studies probe the role of biome enrichment, in particular the addition of helminths, in the treatment of disease. Studies are ongoing in both humans and in animals, with particular attention to the role of biome depletion in cognitive dysfunction.

We discuss the future of human health with a specific focus on our macrobiome friends, parasites, with whom we have co evolved. They are now missing and we are not better off because of it.

 

Please enjoy my conversation with Dr. William Parker,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 11 Issues 39 and 41, Covid Updates 44 and 45

Coronavirus Updates #44 and 45 – Listen to the latest data driven perspectives on the pandemic. Vaccine boosters, MIS and what is happening now are covered. For the written versions please visit: https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter

 

Best,

Dr. M

10 Things Parents Can Do to Prevent Allergies in Their Children ? (Pedcast)

Introduction

Sometimes reality is so counter-intuitive, isn’t it? If you had told me 20 years ago that some of the keys to raising healthy children would be whether a the child’s family owned a dishwasher, whether they had a lot of people living in their home, whether there were pets living inside the house, or whether the children visited or lived near a farm, I would have thought you were a little crazy. It turns out that these factors, along with others, are super important to your children’s ultimate good health. Interested in learning more? Then stay tuned for this fascinating edition of Portable Practical Pediatrics. But before we get started, I want to take a moment to thank today’s sponsor, The TheChildrensTable.com, a food blog specifically designed for parents who have the important responsibility of feeding the little people in their lives. Take your food knowledge to the next level by following TheChildrensTable.com today.  I love it. I know you will too. Now onto today’s post. Continue reading

Are Your Kids Too Clean? (Pedcast)

Voice intro:

Welcome to another edition of Portable Practical Pediatrics. I’m your host, Dr. Paul Smolen, also known as Doc Smo. From the bassinet to the board room, if the topic involves children, we talk about it here. I frequently get asked by the parents of my patients, “Why do so many children have food allergy, asthma, and eczema today? Most of these parents don’t remember their friends having nearly the incidence of allergy that today’s children do and that was just a few decades ago. What is going on, they ask? Well, my answer is that we really don’t know, but we are beginning to get closer to an answer. For years, immunologists and allergists have been talking about something called the Hygiene Hypothesis to explain all of this allergy. Recent observations have made this less of a theory and more of an explanation. Experts are beginning to have some understanding. So in today’s pedcast, I thought we would talk about some of this evidence and introduce you to the current thinking about allergies and children. The hope is if we can understand what is driving the allergy epidemic, we can help protect future kids from suffering from with terrible allergies. Continue reading

Dishwashers Harmful to Kids? (Article)

It turns out there is truth in the statement “The old way is the better way,” according to a recent study that has found an association between dishwashers and the growing prevalence of allergy among children. In this study, Swedish researchers found childhood allergies to be less prevalent in families who hand washed dishes versus those who used modern dishwashing machines. It was just a few generations ago when parents and children alike, hand washed the dishes after dinner. In modern America today, this activity seems to be a only a distant memory. The majority of American families now have the convenience of an electric dishwasher to help with kitchen cleanup. Continue reading