Tag Archives: disease

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 36

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Biome Depletion Theory or Biota Alteration Theory
When we look at risk of disease over time in humans, we need to take stock in what was supposed to be versus what is. If we become mismatched genetically to the environment that we find ourselves in, then we will begin to suffer disease. The work of Dr. William Parker and colleagues is very fascinating here. His understanding of our immune solvency takes us back to a time when macrobes like parasites lived with us in a semi-symbiotic way. Most of them were harmless where a few were pathogenic. This matters tremendously because as we are learning, the microbes that exist within us play a major role in tuning the immune system towards tolerance and effective pathogen killing.
A lot to explore here,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 33

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Coronavirus Update 67

Natural infection provides a much better route to transmission protection than intramuscular systemic vaccination because of the induction of mucosal immunity via IgA and tissue resident T cells. (Tang et. al. 2022) If you can tolerate a natural infection without much morbidity, this seems to be a reasonable choice at this time. This is especially important now with the immune escaping variants of Omicron lineage and the reality of the current vaccine booster pool is lackluster in its effect on transmission. This calculus may change dramatically with a newer Omicron BA.5 specific vaccine that is in the works. And much more this week!

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 29

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Coronavirus Update #65

This week we take another and deeper dive into PACS or long covid. What are the risk factors for it? How does the intestinal microbiome play out in this space? Are there certain bacteria that are associated with a negative outcome? Can we alter them to our advantage? We also take a closer look at the current variants of the Omicron lineage. Finally, we end with a discussion of social media concerns.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 25

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Coronavirus Update 63 plus other stuff – Lots on boosters today while the persistent world of Covid exposure drags on. Omicron US strains: newer variant BA.2 makes up 35% of current case volume based on different parts of the country while omicron BA BA 1.1.529 is at 6% and B 2.12.1 is 59%. Delta is gone by competition. Cases are increasing in some cities with little increase in hospital morbidity and mortality. In essence we are still fairing quite well in the new norm. Quick Hits and other musings!
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 24

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A subset of children may be more susceptible to respiratory infections of viral and bacterial varieties based on some new research. It appears that the microbiomes of the nasopharyngeal respiratory tract and host immune defenses play a major role here. We discuss some new research regarding infection risk. We also discuss snakes, post bite care and avoidance.

More to learn,

Dr. M

Dr. M’s Women and Children First Podcast #19 – Dr. Alessio Fasano – Intestinal Permeability, Microbiome and MIS

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Dr. M’s Women and Children First Podcast #19 – Dr. Alessio Fasano
Intestinal Permeability, Microbiome and MIS
In this podcast, I sit down with Pediatric Gastroenterologist Dr. Alessio Fasano from the Massachusettes General Hospital Department of Pediatric Gastroenterology to discuss the current research on Intestinal Permeability, Microbiomes and MIS, Multi Inflammatory Syndrome in Children .
Dr. Fasano also directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders including celiac disease, and other-gluten-related disorders. He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others.
He recently co authored an excellent book with Susie Flaherty called Gut Feelings. I highly recommend you purchase and read this book. It is an encyclopedia of information regarding gut health, the microbiome and much more.
Enjoy my conversation with Dr. Fasano,
Dr. M

Dr. M’s Women and Children First Podcast – Covid Pathophysiology Deep Dive, Death Risk and Disease Prevention

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Covid Pathophysiology Deep Dive, Death Risk and Disease Prevention

In this weeks podcast we go very deep into the world of why Covid19 was able to produce so much mortality in the United States. Why were we so unprepared to survive as a culture? Why is this virus so capable of hijacking our immune physiology for it’s benefit? What are the upstream risk factors for a bad outcome. But most importantly, we learn the immune based reasons why we are at risk at the micro level leading to concrete pathways to undoing the risk.

Diving deep is sometimes necessary to find the treasure below. This week is one of those journeys.

Dr. M

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