Immune Health

Dr. M’s Women and Children First Podcast #83 – Ana Maria Temple, MD

Dr. Ana-Maria Temple, MD, is an integrative pediatrician known for her whole child approach to children’s health. She studied medicine at the University of North Carolina at Chapel Hill School of Medicine before pursuing pediatric residency training at Penn State Milton S. Hershey Medical Center. In 2017, Dr. Temple further specialized by completing a fellowship in Functional Medicine at the Cleveland Clinic Foundation. She combines conventional medicine with functional and lifestyle-based strategies to address common childhood conditions such as eczema, asthma, and allergies. Dr. Temple has a particular focus on helping families reduce dependence on medications by making sustainable health and wellness changes.

With decades of clinical experience, Dr. Temple has been a vocal advocate for preventive care, emphasizing nutrition, environmental changes, and integrative treatments. She is the author of the two bestselling books Healthy Kids in an Unhealthy World and Ending the Eczema Epidemic. Additionally, Dr. Temple is a sought-after speaker and podcast guest, sharing her expertise on holistic pediatric care through various platforms. Today, we focus on her approach to eczema and children’s health.

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #81 – John Wherry, PhD – Covid, What Did We Learn?

Today, we are honored to have Dr. E. John Wherry, a leading expert in the field of immunology, joining us. Dr. Wherry is the Chair of the Department of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania, where he also directs the Institute for Immunology. His undergraduate degree was obtained at Penn State University before completing his PhD in Immunology at the Thomas Jefferson University.

A thought leader in T cell biology and immune memory, Dr. Wherry’s work has been instrumental in improving therapies for viral infections, vaccines, and immunotherapy treatments. His discoveries in the field of immune exhaustion have had a profound impact on the way we approach treatments for cancer and autoimmune diseases. Widely published in top academic journals including Nature, Cell, and Science, Dr. Wherry is a heavy contributor to Covid research and especially the understandings of long Covid.

Today, we discuss Covid and the current state of the science regarding vaccines, long covid and what we can do better next time there is a pandemic.

Enjoy,

Dr. M

 

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 40/41

Literature Review Week

Why do some people react to mosquitoes so vigorously? There is fascinating data for me in the Nature article, as I see lots of kids that react strongly to mosquitoes while others do not at all. A hyper primed immune reaction makes a lot of sense as the immune system is extra sensitive to the insult in individuals that have chronic allergic phenotypes. They are in effect polarized to see the outside world through an irritant lens and thus react in a more robust way. The cell called GD3 releases Interleukin 3 or IL-3 which is a cytokine signaling molecule that tells skin based sensory neurons to become more sensitive to allergens like house dust mites, environmental molds, and in this case mosquito saliva. Thus, the mosquito saliva induces more of the itch scratch cycle. The effect is to increase the gain sensitivity on the skin to 10. This is likely a main reason why having an allergic child take immunotherapy against allergens that they react to lowers the rheostat for all irritants. It is like a global check on the sensory system. This is another reason to consider SLIT and or SCIT immunotherapy in allergic children… Plus a discussion on the Joe Rogan podcast with Callie and Casey Means.

Enjoy,

Dr. M

 

Dr. M’s Women and Children First Podcast #78 – Elisa Song MD – Healthy Kids Happy Kids

This week I sit down with Dr. Elisa Song to discuss her new book, Healthy Kids, Happy Kids. Dr. Song is a graduate of Stanford University with a degree in political Science. She then attended New York University for her medical degree and finally a stop at the University of California San Francisco for pediatric residency training. In her own words, Dr. Song is a holistic pediatrician. She founded Whole Family Wellness, an integrative pediatric practice in Belmont, CA – one of the first and most highly regarded holistic pediatric practices in the country. She created Healthy Kids Happy Kids – dedicated to empowering parents to take charge of their kids’ health … naturally! She lectures around the world for the Center for Education and Development in Clinical Homeopathy (CEDH), Academy for Pain Research, Institute for Functional Medicine, and Holistic Pediatric Association, A4M among others. In this interview we look at health through a prevention first lens with a deep look at the intestinal microbiome and nutrition. Dr. Song’s immense fund of knowledge is on full display in her book and this interview.

Please enjoy my conversation with Dr. Elisa Song,

Dr. M

Dr. M’s Women and Children First Podcast #77 – Colleen Cutcliffe, PhD – Microbes and Health

This weeks guest is Dr. Colleen Cutcliffe.

Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring.

Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome’s role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition.

Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health.

Please Enjoy my conversation with Dr. Cutcliffe,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 26

Sleep Restriction and Immune Health

It has long been known that sleep is a truth teller of mood. The poorer the sleep quality, the poorer the emotional response. Every parent knows this with a child short on sleep. What are the cellular effects?

From an abstract looking at catch up sleep and human inflammation we find the following: “Despite its prevalence in modern society, little is known about the long-term impact of restricting sleep during the week and ‘catching up’ on weekends. This common sleep pattern was experimentally modeled with three weeks of 5 nights of sleep restricted to 4 h followed by two nights of 8-h recovery sleep. In an intra-individual design, 14 healthy adults completed both the sleep restriction and an 8-h control condition, and the subjective impact and the effects on physiological markers of stress (cortisol, the inflammatory marker IL-6, glucocorticoid receptor sensitivity) were assessed. Sleep restriction was not perceived to be subjectively stressful and some degree of resilience or resistance to the effects of sleep restriction was observed in subjective domains. In contrast, physiological stress response systems remain activated with repeated exposures to sleep restriction and limited recovery opportunity…… and a section on literature review.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 21

Excess Weight Gain, Obesity and Immune Related Diseases in 2 cases
I want to share a few recent case experiences that shed light on the patient provider experience in the context of a collaborative clinic model based on prevention and the patient first mentality.
In the struggle against the US based disease onslaught that is excess weight gain, longevity with the patient remains the greatest winner for a quality outcome. What do I mean when I say this? Let me tell you a story. I care for a wonderful young man who is about to turn 17 years old. I have known him since birth and his struggle with weight has been profound for most of these 17 years…… Plus an article review about weight loss and a recipe of the week.
Enjoy,
Dr. M

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