Tag Archives: disease

Dr. M’s SPA Newsletter Volume 15 Issue 17

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Inflammaging from a Population View

In a landmark study published in Nature Aging on July 7, 2025, researchers challenge a cornerstone of modern gerontology by showing that inflammaging, chronic, age-associated low-grade inflammation, is not universal across all human populations. The abstract states the following: “Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging axis detected in the Italian InCHIANTI dataset comprising 19 cytokines could be generalized to a different industrialized population (Singapore Longitudinal Aging Study) or to two indigenous, nonindustrialized populations: the Tsimane from the Bolivian Amazon and the Orang Asli from Peninsular Malaysia.

We assessed cytokine axis structure similarity and whether the inflammaging axis replicating the InCHIANTI result increased with age or was associated with health outcomes. The Singapore Longitudinal Aging Study was similar to InCHIANTI except for IL-6 and IL-1RA. The Tsimane and Orang Asli showed markedly different axis structures with little to no association with age and no association with age-related diseases. Inflammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialized lifestyles, with major variation across environments and populations.” (Franck et. al. 2025)

The research team analyzed 19 cytokines in over 2,800 individuals from four diverse populations: two industrialized cohorts: Italy’s InCHIANTI and the Singapore Longitudinal Aging Study (SLAS); two non-industrialized, Indigenous groups: the Tsimane of the Bolivian Amazon and the Orang Asli of Peninsular Malaysia.

In Italy and Singapore, the industrialized regions noted classic inflammaging signatures with inflammatory markers like IL‑6, TNF-α, and CRP increased with age, and correlated strongly with age-related chronic diseases such as cardiovascular and kidney disease….. and more on inflammaging…

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 8

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Itaconate, what is it and why does it matter?

Science Heavy – skip to the bold for take home if you want to avoid the science.

The biggest takeaway from this complex science is this: High fat, high sugar diets (Ultra Processed Foods) are associated with decreased itaconate activity and increased inflammation. The science further answers the question of whether we should allow ultra processed food in schools.

Ultra Processed Foods likely reduce itaconate production driving inflammation, metabolic dysregulation, and gut dysbiosis, which could worsen active disease. Lower itaconate levels likely impair your body’s ability to resolve inflammation, potentially leading to prolonged issues with healing and repair. To support itaconate’s anti inflammatory activity, shift away from UPFs toward an anti-inflammatory diet (e.g., Mediterranean, rich in vegetables, omega-3s, and fiber) to reduce inflammation, support gut health, and enhance itaconate’s immune-regulating effects.

Science:…..

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #13 Repost – Dr. Peter Rowe, Chronic Fatigue Syndrome and Long Covid

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Welcome to Dr. M’s Women and Children First, where we dive into the latest insights on health and wellness for women and children. Today, we’re honored to have Dr. Peter Rowe, a world-renowned expert from Johns Hopkins University, joining us to unravel the complexities of chronic fatigue.  Dr. Peter Rowe is a Professor of Pediatrics at the Johns Hopkins University School of Medicine. He is the inaugural Sunshine Natural Wellbeing Foundation Professor of Chronic Fatigue and Related Disorders and serves as the Director of the Chronic Fatigue Clinic at Johns Hopkins Children’s Center. His areas of clinical expertise include chronic fatigue syndrome and other disorders characterized by fatigue and orthostatic intolerance. Dr. Rowe and his colleagues were the first to describe the relationship between chronic fatigue syndrome (CFS) and treatable orthostatic intolerance syndromes, as well as the association between Ehlers-Danlos syndrome and CFS. In this episode, Dr. Rowe and I dive deep into CFS and long Covid for both the parent and the clinician. We set the stage for a better understanding of this complex disorder in order to encourage earlier diagnosis and better therapy. From its impact on daily life to cutting-edge approaches for management, Dr. Rowe brings decades of expertise to help us understand this challenging condition. 

Please Enjoy,

Dr. M

 

Dr. M’s Women and Children First Podcast #86 – Joe Pizzorrno, ND

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Welcome to Dr. M’s Women and Children First, the podcast where we dive deep into the science of health, wellness, and prevention—especially for women, children, and families. Today, we have a truly special guest, Dr. Joe Pizzorno.

Dr. Joe Pizzorno is a world-renowned leader in functional and naturopathic medicine, a trailblazer in environmental health, and the founding president of Bastyr University, one of the most prestigious natural health institutions in the world. With decades of research, policy advocacy, and clinical expertise under his belt, Dr. Pizzorno has been at the forefront of reshaping modern medicine by emphasizing the critical role of nutrition, detoxification, and whole person health in preventing and reversing disease.

He is the author of these books: Textbook of Natural Medicine, The Toxic Solution, Clinical Environmental Medicine, Clinical Pathophysiology and Total Wellness. He is an incredible teacher and sought after speaker worldwide.

Today, we’ll be discussing metabolism and the hidden impact of environmental toxins on women and children’s health, practical detox strategies, and how we can take charge of our well-being in an increasingly toxic world. If you’re looking for science-backed insights and actionable tips to help your family thrive, you won’t want to miss this conversation!

I hope that you enjoy my conversation with Dr. Joe Pizzorno!

Dr. M

Dr. M’s Women and Children First Podcast #84 – Francis Koster Ed.D

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Today, we have an extraordinary guest joining us—Dr. Francis Koster, a man who has spent decades uncovering the invisible forces that shape our environment and, ultimately, our health.

Dr. Koster is the founder of Pollution Detectives, an initiative that combines data-driven science, community collaboration, and advocacy to address environmental issues that impact the air we breathe, the water we drink, and the ecosystems that support our lives. With a focus on actionable solutions, Dr. Koster empowers communities to identify and combat environmental risks, especially those affecting children, who are often the most vulnerable to pollutants.

Through his tireless work, Dr. Koster has inspired countless individuals to take charge of their surroundings and has highlighted the profound connection between environmental stewardship and public health. Today, we’ll dive into his groundbreaking efforts, the stories behind the data, and how we can all become part of the solution to ensure a healthier, safer future for the next generation.

So, without further ado, let’s welcome the innovative and inspiring Dr. Francis Koster to the show!

Enjoy,

Dr. M

Pollution Detectives

Dr. M’s Women and Children First Podcast #83 – Ana Maria Temple, MD

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Dr. Ana-Maria Temple, MD, is an integrative pediatrician known for her whole child approach to children’s health. She studied medicine at the University of North Carolina at Chapel Hill School of Medicine before pursuing pediatric residency training at Penn State Milton S. Hershey Medical Center. In 2017, Dr. Temple further specialized by completing a fellowship in Functional Medicine at the Cleveland Clinic Foundation. She combines conventional medicine with functional and lifestyle-based strategies to address common childhood conditions such as eczema, asthma, and allergies. Dr. Temple has a particular focus on helping families reduce dependence on medications by making sustainable health and wellness changes.

With decades of clinical experience, Dr. Temple has been a vocal advocate for preventive care, emphasizing nutrition, environmental changes, and integrative treatments. She is the author of the two bestselling books Healthy Kids in an Unhealthy World and Ending the Eczema Epidemic. Additionally, Dr. Temple is a sought-after speaker and podcast guest, sharing her expertise on holistic pediatric care through various platforms. Today, we focus on her approach to eczema and children’s health.

Enjoy,

Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 28

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Klotho Part II

Last week we discussed Klotho as a protein that has pleotrophic effects in the body as it relates to cellular aging. This week let us focus specifically on the brain. What are the effects of klotho as it relates to cognition and function over time? Klotho has neuroprotective effects based on studies that show that better cognitive performance in translational models over time occur with the injections of klotho. Klotho is also shown to have neuroprotective effects if naturally elevated, i.e. individuals with host genetics that promote more klotho production over time without being taken or given.

The pivitol research occurred in 2015 in a mouse model of Alzheimers Disease (AD) where Dr. Dena Dubal and colleagues looked at two groups of intervention mice with and without higher levels of Klotho. and a literature review on micro plastics and screentime.

Enjoy,

Dr. M

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