Tag Archives: aging

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 28

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Klotho Part II

Last week we discussed Klotho as a protein that has pleotrophic effects in the body as it relates to cellular aging. This week let us focus specifically on the brain. What are the effects of klotho as it relates to cognition and function over time? Klotho has neuroprotective effects based on studies that show that better cognitive performance in translational models over time occur with the injections of klotho. Klotho is also shown to have neuroprotective effects if naturally elevated, i.e. individuals with host genetics that promote more klotho production over time without being taken or given.

The pivitol research occurred in 2015 in a mouse model of Alzheimers Disease (AD) where Dr. Dena Dubal and colleagues looked at two groups of intervention mice with and without higher levels of Klotho. and a literature review on micro plastics and screentime.

Enjoy,

Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 27

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Klotho Part I
Ok, it is time for a potential log step shift in the human understanding of neurological decline with age starting from birth.
Enter the peptide, (C)Klotho, named after the greek goddess of fate who spins the thread of life for all. The Klotho protein was discovered by researchers looking at mice that aged faster than the general mouse population. These mice were noted to have a shortened lifespan, stunted growth, renal disease, blood vessel calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. (Prud’homme et. al. 2022) When they looked closer, these mice were found to have hypoactive klotho proteins leading to an explosion of research over the past two decades to understand why. The next question was, could the hyperactive state provide an anti aging effect?
The answer was a resounding yes!
and a discussion on fast food.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 11 Issues 48 and 50

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Newsletter #48 – Biological Clock and Aging
What do we really know about aging?
We know that it accelerates under chronic unremitting stress of varied sources. Including – chronic high fat and sugar laden westernized diets, chronic chemical or drug exposure or acute if a toxic load, chronic sedentary behavior, chronic metal sadness or abuse, physical abuse, injury that is profound and much more.
It is no wonder looking at that list that we are aging poorly now despite high quality medical interventions that keep us alive. Thus, what is our biological clock say about our age versus the chronological clock of age. Think of this as how old do you appear biologically or cellularly versus how old you really are by days.
Newsletter #50 – Breastmilk is a Miracle of Evolution
After the birth of a child, a beautiful event occurs and provides a point of visceral connection physically and epigenetically between mom and her babe. That event is breastfeeding. Mother’s milk is an evolutionary marvel whereby a mother dedicates part of her energy stores to her offspring for survival. She gives of herself literally and figuratively even during periods of food scarcity. Over thousands of years, humans have evolved this dynamic and rich fluid to promote species survival in the context of our dependent selves as babies. We have massive brains needing large amounts of energy to grow and mother’s milk is the culmination of the species learned process of survival. Human milk is the perfect dynamic personalized food for an infant to thrive. It is different for each mother child dyad. It changes based on environmental and human flux. It is in simple terms the best food for a newborn while simultaneously being the best medicine for all that ails a newborn.
Enjoy,
DR. M
For the written newsletter visit: https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter