insulin resistance

Dr. M’s Women and Children First Podcast David Katz, MD – Childhood Obesity Part II Repost

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David L. Katz, MD, MPH is a specialist in Preventive Medicine and Lifestyle Medicine, with particular expertise in nutrition.
He earned his BA at Dartmouth College (1984); his MD at the Albert Einstein College of Medicine (1988); and his MPH from the Yale University School of Public Health (1993). He completed sequential residency training and board certification in Internal Medicine (1991) and Preventive Medicine/Public Health (1993). Katz is the founder and former director of Yale University’s Yale-Griffin Prevention Research Center (1998-2019); Past President of the American College of Lifestyle Medicine; President and Founder of the non-profit True Health Initiative; and Founder and CEO of Diet ID, Inc. The recipient of numerous awards for teaching, writing, and contributions to public health, Katz was a 2019 James Beard Foundation Award nominee in health journalism, has been a widely supported nominee for the position of U.S. Surgeon General, and has received three honorary doctorates. Katz has served as a nutrition columnist for O, the Oprah Magazine; an on-air contributor for ABC News/Good Morning America, and with appearances on most major news programs and contributions to most major magazines and leading newspapers, including OpEds in the New York Times and Wall Street Journal.
His most recent book, How to Eat, co-authored with Mark Bittman, is a 2021 IACP Awards finalist and is worth your time. I have had the pleasure of hearing him speak many times over the years and he is an amazing orator and I am blessed to have this hour with him. Today, we dive into the science of childhood obesity and what are the public health pain points that can be pressed on to change the negative trajectory.
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #77 – Colleen Cutcliffe, PhD – Microbes and Health

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This weeks guest is Dr. Colleen Cutcliffe.

Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring.

Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome’s role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition.

Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health.

Please Enjoy my conversation with Dr. Cutcliffe,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 17

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Literature Review
1) In a first of its kind study in mice, we see concrete evidence for how the mitochondria in obese individuals are a root cause of disease based on nutritional input. This fascinating animal translational study gives us insight into how a high fat diet is also a major component of mitochondrial damage through fission and fragmentation leading to worsened cell bioenergetics. The cells have reduced fatty acid oxidation or fat burning capacity due to a single gene’s actions. The end result is a tilt toward fat cell production, fat storage and fat cell inflammation which are associated with diabetes and insulin resistance and ultimately metabolic syndrome. This starts to explain the paradox that is obesity where the person has a ton of stored energy, but has limited capacity to utilize it. It is like having a gas tank of fuel with a gas line that only allows for 1/10th of the flow required for optimal function. Science Daily has an excellent review of this paper. Link below. 
2) Women’s brains change during pregnancy as per a new study. The authors looked at brain changes before and after birth as well as with or without a vaginal delivery route. Their study findings noted transient changes in some brain regions as well as permanent changes in other brain regions that turn on self-reflection and empathy for others…… and a recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 5

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Sugar, Immune Health and Two Studies
Let us start right out of the gate with two studies. #1: Here is the abstract from European Journal of Clinical Nutrition: “Milk contributes with saturated fat, but randomized controlled trials (RCT) on the effects of dairy on the risk of type 2 diabetes (T2D) where dairy is given as whole foods are scarce. The objective of our study was to investigate the long-term effects of semi-skimmed milk on insulin sensitivity and further to compare milk with sugar-sweetened soft drinks (SSSD). A secondary analysis of a 6-month RCT with 60 overweight and obese subjects randomly assigned to 1 L/d of either milk (1.5 g fat/100 mL), SSSD, non-calorie soft drink (NCSD), or water was conducted. Insulin sensitivity was evaluated by oral glucose tolerance test (OGTT) and plasma free fatty acids. Second, fasting blood lipids, blood pressure, and concentration of plasminogen activator inhibitor-1 were assessed……and more on antibiotic resistance.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 1

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Literature Reviews have been very popular. Thus, 2024 will start with science update.

1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease. How does circadian biology play into this reality? From Cell Metabolism: “Circadian disruptions impact nearly all people with Alzheimer’s disease….plus a discussion on water, dehydration and prevention as well as a recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 35

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Here is a short written version of the fructose story in tandem with the podcast with Dr. Rick Johnson where we go deep. We are going to discuss the survival switch and fructose metabolism in specific as it relates to pregnancy. It will be another life changing discussion for many of us. Fructose is the natural sugar found in fruit, honey and root vegetables. Historically, humans consumed fructose in these natural whole foods and did so moderately. Since the 1970’s, there has been a major rise in fructose consumption, primarily as a beverage…. Also, a discussion of fiber and neurodevelopment as well as a review of the book the Carpenter and the Gardener by Alison Gopnik.
Enjoy,
Dr. M

 

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 6

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This week week look at a piece by David Katz: “I imagine -and in select cases know- that many of my colleagues were encouraged and gratified to hear that the NIH is allocating a sizable sum to the pursuit of precision nutrition. Some number of my colleagues will be directly involved in those research efforts, and others are simply pleased to see nutrition getting some small measure of the attention we agree it warrants. I can appreciate these reactions, but in my case, the response felt more like a wave of nausea accompanied by echoes of “here we go again, again…..”

We also look at some recent studies in the aging space. Two studies by Dr. Sinclair and Dr. Macip looking at age reversal ability. From the David Sinclair Lab at Harvard we see first of its kind data regarding the ability to identify epigenetic marks in mice as the etiology or biomarker of aging. This is nothing short of an amazing discovery. Listen to Podcast #2 with the father of epigenetics Dr. Randy Jirtle to gain a foothold in this world and then listen on.

Enjoy,

Dr. M

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