Tag Archives: neurology

Dr. M’s SPA Newsletter Volume 15 Issue 15

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Systemic Maternal Inflammation and Neurodevelopment: The Role of IL-6 and IFN-γ in Autism Spectrum Disorder

I just returned from Estes Park, Colorado where I presented a lecture on the Growing Brain/Mind – a tour through the underpinnings of childhood neurological changes that we call Autism. The timing is perfect for this article to be written.

In an era when chronic disease in children is rising at an unprecedented pace, the search for root causes must include an honest inquiry into the conditions present during fetal development. The review article by Majerczyk and colleagues, Systemic Maternal Inflammation Promotes ASD via IL-6 and IFN-γ, brings forward a critical piece in this puzzle that I began to explore a few years ago when writing a book. It connects the dots between maternal immune dysregulation and long-term neurodevelopmental outcomes, specifically autism spectrum disorder (ASD). Through a synthesis of clinical data and animal research, the authors make a compelling case for the centrality of two inflammatory messengers, interleukin-6 (IL-6) and interferon-gamma (IFN-γ), in shaping fetal brain development during gestational stress. The key words here being GESTATIONAL STRESS, the recurring scientific theme for ASD development, not vaccines… and some literature reviews.

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 6

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This is such an important topic to cover, even for a pediatrician. Dementia!

This problem is slated to exponentially worsen in the coming decades. And it starts at birth!

​In the intricate landscape of Alzheimer’s disease (AD), emerging research underscores a pivotal yet under explored facet for the why?, the brain’s energy immunometabolism. A recent study by Patel et al., titled “Global Energy Metabolism Deficit in Alzheimer Disease Brain,” delves into this domain, revealing significant metabolic disruptions that may illuminate novel upstream causes and possible therapies.

​ For the better part of the last few decades, all AD research centered on the amyloid and tau plaques as the causative problem. However, billions of dollars and many drugs later, this hypothesis has crashed and burned. Failed therapies coupled to the skyrocketing volume of AD patients in the US over the next few decades will burden the US healthcare system and families alike. Folks, we need better answers and therapies rapidly. Thus, I have been following this information on and off over the years looking for answers. Last month, Dr. David Perlmutter gave an excellent lecture on microglial cells in the brain and their impact on AD and neurocognition in general. One paper that he cited was the Patel paper. Let’s look at it.

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 1

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Some Key Literature Review Studies from Year 14

This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward.

1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease…..Plus a to do list and recipe of the week.

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 18

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Unraveling the Mysteries of the Amygdala: A review of a section of the book Behave by Robert Sapolsky
In the world of neuroscience, Robert Sapolsky stands as a luminary, a maestro of unraveling the intricate dance of our brain’s circuitry. Among the many deep dives that he delves into, his perspective on the amygdala resonates profoundly for me. The amygdala emerges not as a mere anatomical curiosity as he decides that rather than reducing the amygdala to a simplistic seat of fear and aggression, he highlights its diverse functions, emphasizing its involvement in the vast array of behaviors and experiences. It is a narrative view of the why the brain developed as it did to aid us in the fight against pathogens, predators and stress. Sapolsky’s take on the amygdala is nothing short of revelatory, akin to a seasoned detective peeling away layers of a perplexing case. There are diverse neuronal pathways in this almond-shaped structure nestled deep within our temporal lobes and they have profound purpose. The amygdala emerges not merely as a primal seat of fear and aggression, but as a nuanced orchestrator of our emotional lives. All mammals have emotional responses that are split second to threat, joy and relationship. This is mediated……Plus a section on DNA and memory. Finally, a recipe.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 51

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Literature Review
1) High resting cardiac vagal tone or control, CVC, is associated with more flexible emotional responding to external stressful stimuli. With regard to vagal changes the evidence shows us that stress will decrease CVC . (Balzarotti et. al. 2017)
Being relaxed and not stressed out is always associated with better cellular physiology. CVC is a marker of relaxation and thus emotional control. Whenever you find yourself emotionally dysregulated, there is a good chance that your vagal tone is off. Work to meditate, exercise and relax which will increase CVC and help you cope.
2) Continuing on the same theme….. plus a discussion on maternal neural hormonal rewiring, and a recipe of the week.

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 4

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This week we do a literature review looking at Neurology with specific stops at sleep loss and emotional regulation, APOE4 and Alzheimer’s Disease, memory consolidation with sleep versus wake, gaslighting and more . We also look at potassium as a mineral of necessity. We finish with obesity and Semaglutide.   Enjoy, Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 1

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Covid update #77 with quick hits on vaccines in young adults, POTS or hypotension following Covid 19 as well as obesity and Sars2. Non covid research looking at the brain.

From Nature Communications: “Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from start to end… Here we show that over 30% of species, genes and pathways tested have altered abundances in PD, depicting a widespread dysbiosis.”

Enjoy,

Dr. M

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