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Dr. M’s Women and Children First Podcast #107: Sundeep Dugar, PhD – Drug Discovery


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On today’s episode of Dr. M’s Women and Children First Podcast, we welcome a scientist whose work has quietly shaped the cardiovascular health of millions around the world.

Dr. Sundeep Dugar is a pharmaceutical innovator, inventor, and industry leader with more than three decades at the forefront of drug discovery. He is best known as a co-inventor of ezetimibe — marketed as Zetia® — a landmark cholesterol-lowering medication that transformed lipid management by targeting intestinal cholesterol absorption. He also co-inventor of the combination therapy Vytorin® (ezetimibe plus simvastatin), expanding treatment options for patients at high cardiovascular risk. For this groundbreaking work, Dr. Dugar and his colleagues received the prestigious 2005 National Inventor of the Year Award from the Intellectual Property Owners Association and the Heroes of Chemistry award from the American Chemical Society. Across his career, Dr. Dugar has contributed to more than 140 patents and has authored over 70 scientific publications, reflecting a lifetime devoted to translating chemistry into real-world therapies.

He is currently the founder of Aayam Therapeutics, where he leads efforts to develop innovative, accessible medicines through collaborative global research. He also serves as Co-Chief Executive Officer of Blue Oak Nutraceuticals, advancing a novel mitochondrial-targeted compound known as Mitokatlyst™, designed to stimulate mitochondrial biogenesis and cellular energy — with potential implications for muscle strength, metabolic health, cardiovascular function, and inflammation. He is the first one to decipher the mechanism by which exercise induces mitochondria levels. Mitokatlyst mechanism of action mimics this process.

Dr. Dugar’s scientific journey spans continents and some of the world’s premier institutions. He earned both his Bachelor’s and Master’s degrees in Organic Chemistry from the University of Delhi, completed his PhD in Chemistry at the University of California, Davis, and pursued postdoctoral research at ETH Zürich in Switzerland and at Cornell University.
Today, we’ll explore the story behind major pharmaceutical breakthroughs, the science of mitochondrial health, and what the future of therapeutics may look like when innovation meets global accessibility.

Please join me in welcoming Dr. Sundeep Dugar.

Dr. M’s Women and Children First Podcast #106: Nayan Patel, PharmD – Glutathione


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Welcome back to Dr. M’s Women and Children Firsts Podcast. Today’s conversation sits at the crossroads of chemistry, skepticism, and clinical innovation.

Our guest is Nayan Patel, a pharmacist with more than three decades inside the world of drug formulation and delivery. He is an alumnus of the University of Southern California School of Pharmacy, where he now serves as adjunct faculty, teaching advanced biochemistry and compounding science. Over the years, he has become an international educator on one molecule that refuses to stay quiet: glutathione.

Dr. Patel is the founder of Auro Wellness, launched in 2011 with a specific mission—stabilize glutathione and solve its delivery problem. His work led to the development of the Auro GSH™ Antioxidant Delivery System, a topical approach designed to improve absorption of this notoriously fragile molecule. He is also the author of The Glutathione Revolution, a deep dive into how glutathione influences detoxification, aging, energy production, and immune resilience.

If you’ve spent time in integrative medicine, you’ve heard glutathione called the “master antioxidant.” That phrase can sound like marketing, but the biology is real. Glutathione is a three–amino acid peptide central to redox balance, mitochondrial function, immune signaling, and cellular survival. It does not just neutralize oxidative stress; it regulates how cells respond to it.

The challenge is delivery. Oral glutathione is largely broken down in the gut. IV glutathione works, but it’s impractical for most families. Precursors like NAC depend on intact metabolic pathways that may not be operating optimally in states of chronic stress or inflammation.
Dr. Patel asked a disruptive question: what if the bottleneck isn’t production—but delivery?

Today we unpack the science and the skepticism around transdermal glutathione. Can a molecule like this meaningfully cross the skin barrier? What does stabilization actually require? And how does independent pharmaceutical innovation differ from traditional drug development pathways, which are often constrained by economics as much as biology?

For those of us caring for women and children—where oxidative stress, immune dysregulation, mitochondrial strain, and toxic burden intersect in everything from complicated pregnancies to neurodevelopmental challenges—this conversation matters. Not as a silver bullet. Not as a miracle spray. But as an exploration of foundational physiology and thoughtful delivery science.

This is a discussion about how molecules move, how systems adapt, and how asking better questions can reshape clinical practice.
Let’s dive in.

Dr. M

Auro Wellness

Dr. M’s Women and Children First Podcast #105: Carrie Jones, ND – Hormone Literacy

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Dr. Carrie Jones, ND, MPH

Hormone Literacy

Welcome back to Dr. M’s Women and Children First, where we step back from symptoms and ask a more interesting question: how does the female hormonal system actually develop, adapt, and sometimes struggle across a lifetime?

Today’s conversation spans that entire arc, from early life, to puberty, to fertility and more with someone who has spent more than two decades living inside that complexity.

My guest is Dr. Carrie Jones, an internationally recognized speaker, consultant, author, and educator in women’s health and hormones. Many know her as the “Queen of Hormones,” but what really defines her work is not titles, it’s her ability to translate very complex endocrinology into biology that actually makes sense.

Dr. Jones is a naturopathic physician who completed a two-year residency focused on women’s health and endocrinology. She holds a Master of Public Health, was one of the very first clinicians to become board certified through the American Board of Naturopathic Endocrinology, and is a Menopause Society Certified Practitioner.
She helped shape how an entire generation of clinicians think about hormone testing and interpretation as the first Medical Director at Precision Analytical, the creators of the DUTCH test, and later as the first Head of Medical Education at Rupa Health. She’s served on Under Armour’s Human Performance Council, consulted for multiple women’s health and laboratory companies, and now serves as Chief Medical Officer at NuEthix Formulations.

Many of you will recognize her voice from the Root Cause Medicine Podcast, which reached more than ten million downloads, and she now hosts her own show, Hello, Hormones, where she continues to explore how hormones shape mood, metabolism, immunity, fertility, and aging.

But what makes today’s conversation especially important is this: we’re not just talking about menopause, or cycles, or lab values.

We’re asking a bigger question.

How have female hormones changed across generations?

How early life nutrition, stress, environment, and metabolic health shape the hormonal story from birth forward.
And how modern exposures, from ultra-processed diets to endocrine-disrupting chemicals, may be quietly rewriting the biology of women long before symptoms ever appear.

This is a systems-level conversation about development, resilience, and adaptation, and few people are better equipped to guide us through it than Dr. Carrie Jones.

Dr. M

@dr.carriejones
@dr.carriejones
https://www.youtube.com/@drcarriejones


www.drcarriejones.com

Dr. M’s Women and Children First Podcast #104: Maeve O’Connor, MD – Allergy and Immune Literacy


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Today, I’m joined by Dr. Maeve O’Connor, a board-certified allergist and immunologist practicing in Charlotte, North Carolina.
Dr. O’Connor’s training reflects both rigor and range. She completed dual undergraduate degrees at the University of South Carolina Honors College with a Bachelor of Science in Biology and a Bachelor of Arts in Spanish before earning her medical degree at the University of South Carolina School of Medicine. She then completed her internship and residency at the University of Texas and its affiliated hospitals in Houston, where she served as Chief Medical Resident.

Her subspecialty training in Allergy and Immunology was completed at the National Jewish Medical and Research Center in Denver consistently ranked the number one respiratory hospital in the United States where she developed deep expertise in asthma, allergic disease, and immune dysregulation. She further expanded her clinical lens through fellowship training in Integrative Medicine at the University of Arizona from 2013 to 2015.

Clinically, Dr. O’Connor works at the intersection of pediatrics, immunology, and real family life where eczema isn’t just a rash, food reactions aren’t just labels, and immune symptoms rarely fit neatly into algorithmic boxes. Her work emphasizes careful diagnosis, evidence-based treatment, and avoiding both over-medicalization and missed pathology.

In a time when allergy medicine is often reduced to test results and avoidance lists, Dr. O’Connor brings a grounded, thoughtful approach helping families and clinicians distinguish what’s truly allergic, what’s inflammatory, what’s developmental, and what’s simply noise.

Today, we’ll explore how allergic disease actually presents in children, why mislabeling is so common, how early immune signals shape long-term health, and how pediatricians and specialists can collaborate more effectively without fear-based medicine.

This is a conversation about immune literacy, clinical nuance, and doing better for children in a world where their immune systems are under increasing pressure.

I’m excited to welcome Dr. Maeve O’Connor.

Dr. M

Dr. M’s Women and Children First Podcast #69 Repost – Stephen Porges, Ph.D. – Polyvagal Theory


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This week I sit down with Dr. Stephen Porges, a Distinguished University Scientist at Indiana University where he is the founding director of the Traumatic Stress Research Consortium. He is Professor of Psychiatry at the University of North Carolina, and Professor Emeritus at both the University of Illinois at Chicago and the University of Maryland.

He served as president of the Society for Psychophysiological Research and the Federation of Associations in Behavioral & Brain Sciences and is a former recipient of a National Institute of Mental Health Research Scientist Development Award. He has published more than 400 peer-reviewed papers across several disciplines including anesthesiology, biomedical engineering, critical care medicine, ergonomics, exercise physiology, gerontology, neurology, neuroscience, obstetrics, pediatrics, psychiatry, psychology, psychometrics, space medicine, and substance abuse. In 1994 he proposed the Polyvagal Theory, a theory that links the evolution of the mammalian autonomic nervous system to social behavior and emphasizes the importance of physiological state in the expression of behavioral problems and psychiatric disorders. The theory is leading to innovative treatments based on insights into the mechanisms mediating symptoms observed in several behavioral, psychiatric, and physical disorders.
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He is the author of multiple books on his Polyvagal Theory: including the Neurophysiological foundations of Emotions, Attachment, Communication, and Self-regulation, as well as Polyvagal Safety: Attachment, Communication, Self-Regulation. His newest book cowritten with his son is called Our Polyvagal World, How Safety and Trauma Change Us. Dr. Porges is the creator of a music-based intervention, the Safe and Sound Protocol ™ (SSP), which is used by therapists to improve social engagement, language processing, and state regulation, as well as to reduce hearing sensitivities.

This is such a fascinating conversation. He brings the worlds of psychiatry and anthropological physiology into union for us to understand the why of trauma reactions and the future unwinding that is now possible. This is a must listen to conversation if you know anyone with trauma history.

Please enjoy my conversation with Professor Porges,
Dr. M

Dr. M’s Women and Children First Podcast #103: Sam Yanuck, DC – Cogence

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Today on Dr. M’s Women and Children First, we’re joined by Dr. Sam Yanuck, a clinician-educator who has spent more than three decades translating immunology from the bench to the bedside. Dr. Yanuck has been in private practice since 1992 and is the creator of Cogence Immunology, one of the most widely respected functional immunology training programs in the world. Through Cogence, he has trained over 9,900 clinicians internationally to think mechanistically about immune signaling, chronic inflammation, autoimmunity, and the complex, often nonlinear patterns that define chronic disease.

What sets Dr. Yanuck apart is his insistence on precision. His work focuses on understanding the immune system as a dynamic network—one shaped by timing, context, feedback loops, and individual biology—rather than a collection of isolated lab values or diagnoses. In his clinical model, chronic illness is not random; it reflects an identifiable matrix of immune, metabolic, environmental, and regulatory factors that can be mapped, understood, and addressed.

In today’s conversation, we’ll explore how modern immunology reshapes clinical thinking around autoimmunity, chronic inflammatory disease, and long-term health—especially in complex patients where standard frameworks fall short.
This is a deep dive. If you care about mechanism, signal over noise, and treating patients with both scientific rigor and biological humility, this episode is for you.

Today, we’re stepping outside the sterile lab and into the wild world of evolutionary biology — where our immune system didn’t emerge in a vacuum, but in dirt, in danger, and in the delicate dance between microbe and mammal.

Join me and Dr. Sam Yanuck -the clinician, the teacher, and one of the best translators of complex immunology into something both clinically useful and biologically beautiful.

Dr. M

Dr. M’s Women and Children First Podcast #102: Jeremy Goldberg – Life Begins


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This weeks Guest is Dr. Jeremy Goldberg. He styles himself as a compassion cultivating day making change agent/empathy collecting not quitting word wizard/chief burrito appreciator aspiring to inspire/struggle overcoming ranter in charge/ferocious idealist/never giver upper/a love bombing kindness pirate. What he really does, in my mind, is write and teach the world to project love and kindness where it is not layered enough. On his website he writes: My mission is to make kindness cool, empathy popular, and compassion commonplace. As part of that purpose, I write articles, send emails, host retreats and workshops, give TEDx talks, coach clients, host a podcast, write books, and make spoken word poetry videos. My name is Jeremy, I founded Long Distance Love Bombs, and I am fucking stoked to meet you. Send me an email and let’s get going: LongDistanceLoveBombs at gmail dot com. We breakdown words, relationship, connection and being happy in a world of silly tribal divisiveness!

In this conversation we discuss his experience as a new father and the initiation of fatherhood. “I have been wiped out and annihilated by parenting and the initiation of fatherhood. Hands down, brutally, face dragged along the hot coals of the initiation….” There are so many real, honest, open truths dropped along the winding road of this discussion. If you are young and ready to understand the world of fatherhood, this is a conversation for you!

Dr. M

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