Maternal Health

Dr. M’s Women and Children First Podcast #77 – Colleen Cutcliffe, PhD – Microbes and Health

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

This weeks guest is Dr. Colleen Cutcliffe.

Dr. Colleen Cutcliffe is a researcher and a thinker with persistence. Throughout history, these are the human qualities that lead people to develop amazing products and lead projects for the world to benefit from. Her story is one of discovery, passion and caring.

Dr. Cutcliffe holds a Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and a B.A. in Biochemistry from Wellesley College. Her scientific background is complemented by her experience in managing both research and operations teams in the biotech sector. Before founding Pendulum Therapeutics, she held senior positions at Pacific Biosciences and Elan Pharmaceuticals, where she was instrumental in developing various technological platforms. She is the co-founder and CEO of Pendulum Therapeutics, a biotechnology company focused on developing innovative solutions to improve gut health through microbiome-based interventions. With over 20 years of experience in the biotechnology industry, Dr. Cutcliffe has become a recognized leader in microbiome science, applying her expertise to bridge the gap between cutting-edge research and practical, consumer-facing health solutions. At Pendulum Therapeutics, Dr. Cutcliffe has led the development of novel probiotic formulations specifically designed to address metabolic diseases like type 2 diabetes. Her work has been pivotal in the growing recognition of the microbiome’s role in human health, pushing forward the concept of targeted probiotics as a potential therapeutic option. Under her leadership, Pendulum Therapeutics has gained recognition for its scientific rigor and innovative approaches to personalized nutrition.

Today, we discuss the story of her discovery and the fact that her work is the beginning of a hopeful wave of change for humans through gut microbiome manipulation. Dr. Cutcliffe helps us understand the basics of the microbiome, what helps it stay balanced and conversely, what upsets it. How does it support our metabolism and health in general. The main thrust of her work comes into the spotlight with Akkermansia mucinophilia, a keystone species for positive health.

Please Enjoy my conversation with Dr. Cutcliffe,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 31

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Epigenetics and Pregnancy
Epigenetics is the study of environmental signals and their effects on our genes. Our genes are not altered so much as they are read and used differently based on the environmental inputs. Epigenetic effects are critical during the pregnancy period as the environmental signals can alter an offspring’s outcome both in good and bad ways. Making sure that we control for better environmental signal exposure while pregnant can go a long way to protecting our children’s DNA from dysfunction and thus their outcome with health. It is well known that chemicals are generally negative insults to our epigenome while anti-inflammatory whole foods are positive. These epigenetic marks can be conserved over multiple generations making them extraordinarily beneficial or dangerous. Here we will discuss the lifestyle mitigating factors for a positive pregnancy and newborn outcome….plus an ode to Brenda Wassum.
Dr. M

Dr. M’s SPA Audiocast Newsletter Volume 14 Issue 28

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Klotho Part II

Last week we discussed Klotho as a protein that has pleotrophic effects in the body as it relates to cellular aging. This week let us focus specifically on the brain. What are the effects of klotho as it relates to cognition and function over time? Klotho has neuroprotective effects based on studies that show that better cognitive performance in translational models over time occur with the injections of klotho. Klotho is also shown to have neuroprotective effects if naturally elevated, i.e. individuals with host genetics that promote more klotho production over time without being taken or given.

The pivitol research occurred in 2015 in a mouse model of Alzheimers Disease (AD) where Dr. Dena Dubal and colleagues looked at two groups of intervention mice with and without higher levels of Klotho. and a literature review on micro plastics and screentime.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 20

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

“It is your reaction to an adversity not the adversity itself that determines how your life’s story develops.”
Dieter Uchtdorf
WHY?
What are the Underpinnings of Disease?
What have we really learned over the last one to two hundred years of medicine?
We left an era where infections killed the majority of children and adults, especially during childbirth and the first 5 years of life. Science gave us antimicrobial medicines and vaccines that altered this landscape and humans began to live decades longer.
Medicine had conquered disease. However, it was not so. Insidiously, these victories were met with new problems called diseases of aging – heart disease, asthma, autoimmunity, diabetes, cancer, obesity, dementia and others…… and a literature review.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 19

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

The Book that I never published. It is time for me to take another look at the mother child story in book form. In 2019, I embarked on a project of writing a book about maternal health and WHY it matters tremendously that we address the issues driving offspring dysregulation. The time since has ushered in an era of podcast guests that in some instances have solidified my beliefs on knowns while also shattering some beliefs leading to new ideas. Over the coming weeks, I am going to relook at this topic.
Part of this project is going to be taking a page out of the Derek Sivers’ book writing style, brevity and meaning are paramount. I am naturally hyper verbose and my writing style follows this reality. Thus, I am going to fight my natural style and desires in an effort to make this book shorter, much shorter and still powerful in delivery.
Here goes!
WHY?
The story of normal maternal health and how we are disrupting it in modern America…….Also a Literature review and recipe of the week!
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 17

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Literature Review
1) In a first of its kind study in mice, we see concrete evidence for how the mitochondria in obese individuals are a root cause of disease based on nutritional input. This fascinating animal translational study gives us insight into how a high fat diet is also a major component of mitochondrial damage through fission and fragmentation leading to worsened cell bioenergetics. The cells have reduced fatty acid oxidation or fat burning capacity due to a single gene’s actions. The end result is a tilt toward fat cell production, fat storage and fat cell inflammation which are associated with diabetes and insulin resistance and ultimately metabolic syndrome. This starts to explain the paradox that is obesity where the person has a ton of stored energy, but has limited capacity to utilize it. It is like having a gas tank of fuel with a gas line that only allows for 1/10th of the flow required for optimal function. Science Daily has an excellent review of this paper. Link below. 
2) Women’s brains change during pregnancy as per a new study. The authors looked at brain changes before and after birth as well as with or without a vaginal delivery route. Their study findings noted transient changes in some brain regions as well as permanent changes in other brain regions that turn on self-reflection and empathy for others…… and a recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 12

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Pregnancy is a super important time. Do not take by inhalation, ingestion or other exposure anything that is a potential toxin for the body.
Things to avoid:
1) Caffeine – in low to minimal doses, it is clear that caffeine is safe for pregnant women and their offspring. Caffeine easily crosses into the placenta and thus the baby’s circulation. In utero babies cannot metabolize caffeine well putting them at risk with increasing exposure. The data does not support the same reality for more moderate to high doses. Caffeine is known to raise blood pressure and heart rate in all users in variable numbers based on metabolism capabilities…… plus a literature review and a recipe.
Enjoy,
Dr. M

1 2 … 4