Inflammation

Dr. M’s SPA Newsletter Volume 14 Issue 47

Sulfurophane and health – It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023)

Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body’s resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

Dr. M’s SPA Newsletter Volume 14 Issue 46

Lymphatics – Refresher

Lymphatics – a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. By transporting fats , lymph is involved in vitamin movement to tissues and cells for Vitamins A, D, E, K. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease.

“Traditionally considered a passive route for transport of fluid, immune cells, and lipoproteins, lymphatics are now known to be active players in major physiological and pathophysiological processes. Until recently, lymphatic vessel dysfunction was mainly associated with primary and secondary lymphedema. Unexpectedly, however, lymphatic vascular defects have been uncovered in conditions such as obesity, cardiovas- cular disease, inflammation, hypertension, atherosclerosis, Crohn’s disease, glaucoma and various neurological disorders such as Alzheimer’s disease.” (Oliver et. al. 2021)…and a discussion on chemicals in school food.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 39

Section I

Understanding the Action and Use of GLP-1 Agonists in Children – A Pediatrician’s Viewpoint

The United States, like much of the developed world, is facing increasing rates of childhood obesity and related health concerns. Despite years of research and various efforts, addressing this public health issue remains a complex challenge.

This article reviews the potential mechanisms, benefits, and considerations for using GLP-1 agonists in children based on the current scientific understanding. While early research is promising, the application of these treatments in children requires careful consideration and should always be done in consultation with a healthcare provider.

As a pediatrician, I recognize that while the science behind these treatments is evolving, it’s important to remember that individual responses to treatments can vary. For children, every approach needs to be carefully weighed, considering their unique developmental needs…..

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #79 – Robert Lustig, MD – Obesity Epidemic

Welcome to the podcast! Today, I am thrilled to have a true pioneer in the field of metabolic health, Dr. Robert Lustig, MD, joining us. Dr. Lustig is a neuroendocrinologist and Professor Emeritus of Pediatrics in the Division of Endocrinology at the University of California, San Francisco. He is best known for his groundbreaking work on the intersection of diet, obesity, and metabolic disease, particularly his deep dive into the role of sugar as a driving force behind many of today’s chronic health issues.

As the author of several influential books, including Fat Chance, The Hacking of the American Mind and Metabolical, Dr. Lustig has been a vocal advocate for public health, helping to raise awareness about the harmful effects of processed foods, particularly refined sugars. His research has been instrumental in shifting the conversation around nutrition, focusing on the biological impacts of sugar and the ways it contributes to insulin resistance, obesity, and metabolic syndrome. His most recent paper entitled Obesogens, A Unifying Theory for the Global Rise in Obesity in the International Journal of Obesity – Nature is a ground stirring take on the current research.

We are excited to explore his latest insights into metabolic health and the science of obesity, and how we can apply this knowledge to improve our own well-being. Let’s welcome Dr. Lustig to the show!

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 35

Children are and always will be a marker of a society’s quality and focus on their health. When we look at the landscape of childhood health trajectories, we see a declination in quality and an inclination toward diseases of immune dysregulation and underlying chronic unchecked inflammation. What is the genesis point, or where is ground zero?

For me, that answer is the newly understood ecosystem called the intestinal infantile microbiome.

What is the Intestinal Microbiome?

The intestinal microbiome is a complex and dynamic community of microorganisms that plays a crucial role in all mammalian health, particularly in the early stages of life. The development of the human infant intestinal microbiome has profound implications for the child’s immune system, tolerance to the outside world, metabolism, and health trajectory.

Understanding the factors that influence the establishment and evolution of this microbiome can help in devising strategies to promote optimal health from infancy through adulthood. This article dives deep into the key aspects of the development of the infant intestinal microbiome, highlighting the critical stages, influencing factors, and long-term health implications.

How Do Infants Establish Their Gut Microbiome?…..

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 21

Excess Weight Gain, Obesity and Immune Related Diseases in 2 cases
I want to share a few recent case experiences that shed light on the patient provider experience in the context of a collaborative clinic model based on prevention and the patient first mentality.
In the struggle against the US based disease onslaught that is excess weight gain, longevity with the patient remains the greatest winner for a quality outcome. What do I mean when I say this? Let me tell you a story. I care for a wonderful young man who is about to turn 17 years old. I have known him since birth and his struggle with weight has been profound for most of these 17 years…… Plus an article review about weight loss and a recipe of the week.
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #72 – Blaine Leeds D.D.S. – Oral Health and Sleep

This week I sit down with Dr. Blaine Leeds to discuss oral health, sleep apnea, bedwetting and more.
Dr. Leeds is a leader in the dental field. He speaks nationally on tele-dentistry, oral health and dental treatments for sleep disordered breathing and sleep apnea. He is a graduate of Arkansas Tech with a Bachelors degree in Chemistry before attending the University of Tennessee School of Dentistry where he graduated with honors. His skills in dentistry have also spurned many technological companies to help dentistry reach far locations. He is the author of, What happens when your child doesn’t sleep? a book exploring the connection between oral motor function, anatomy and sleep. This is a very important topic as poor sleep will dominate a child’s behavior in a negative way. He has been a guest on many major news networks sharing this wisdom.
Today we sit down to dissect the issues of oral health, sleep and a whole child approach. The exploration is exactly what we need, root cause analysis and treatments based on the reasons not the symptoms.
Please enjoy my conversation with Blaine Leeds,
Dr. M