Tag Archives: prevention

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 27

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Let us head back to the headwaters of HDL biology to find some more answers. If you did not read the original HDL piece or remember the basics of HDL biology, go back to Newsletter V13 #15 for a review. HDL as an associated biomarker of death risk has a U shaped curve with higher all cause mortality at very low and high levels of volume. Let us understand why? (Madsen et. al. 2017) Anything that causes more LDL, low density lipoproteins, to stay in circulation will raise one’s risk of ASCVD or heart attack. The historical reality (as I have discussed for years) for why we would have these genomic mutations to have more LDL particles in circulation is 1) as a protection mechanism against bacterial infections which were common for thousands of years. The HDL and LDL particles have receptors on their surface to grab bacterial cell wall debris like LTE or LPS and remove them via the liver. This is a massive beneftit to the human species until recent times. 2) as a storage mechanism for calories/recirculation of metabolically expensive cholesterol. (Maile et. al. 2020)(Feng et. al.. 2019)(Trinder et. al. 2021)…….
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #50 – Richard Johnson, MD – Fructose and Perinatal Issues

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This weeks guest is my favorite researcher, Dr. Richard Johnson.
He is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book.
This podcast will follow up on the original conversation, podcast #14, and the exceptional work of Dr. Johnson this time looking at how we are mismatched metabolically for the environment of modern America and our food systems from the maternal health and perinatal perspective.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 24

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Breastfeeding Versus Formula
Science versus Opinion
I read with somewhat of a frustrated feeling a recent article in Scientific American entitled: It’s Okay Not to Breastfeed by Kavin Senapathy. In principle, the reality of this statement is reasonable. Then you read the article as to what makes this reasonable. She states: “Exclusive breastfeeding is not imperative, and the “breast is best” mantra can be harmful to babies and parents, especially among marginalized people.”(K. Senapathy 2023) Again, at first blush this may seem reasonable. Let’s dig into the science and the truth of breast versus cow milk based formula for optimal health for a child. Does formula in all of its forms work for infant nutrition in order to grow and survive in a reasonable way? The answer is a resounding yes, however, this does not tell the whole story, far from it…..
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #49 – Marcel Nold, MD – Neonatal Immunology

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This weeks guest is Professor Marcel Nold, MD. Dr. Nold is a clinician scientist in the research environment of neonatal immunology and microbiomes at Monash University in the city of Monash in Melbourne, Australia. Professor Nold received his Doctor of Medicine degree at the JW Goethe-University at Frankfurt am Main, Germany, including final year rotations in Zürich (Switzerland), Montréal (Canada) and Capetown (South Africa). For his biomedical research training he spent six years at the Pharmazentrum at Frankfurt am Main and three years as a research Fellow at the laboratory of Professor Dinarello, at the University of Colorado Denver. In 2009 he was recruited to The Ritchie Centre in Melbourne and finished his specialist training at Monash Newborn. Professor Nold is a leading researcher worldwide in the field of immune cytokine signaling and was the key contributor to identifying Interleukin 37 or IL37. His research has been published in the journals Nature Immunology, Science Immunology and many others. His academic Inflammation in Neonatal Diseases Research Group and his industry programs aim to characterise underlying pathways of inflammation in early life diseases, with a focus on interventional immunology in cardiopulmonary and intestinal diseases of the preterm.
For the purposes of this interview, Dr. Nold is a researcher with a view of the maternal child dyad that is prevention focused and health span conscious. His research has led to many critical discoveries in the neonatal health space that I find deeply intriguing. We get into some deep immunology at times which is critical for total understanding.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 23

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Literature Review: This week we discuss articles about the Inhalation of polyamides or nylon in microsizes, masking and effectiveness, cannabis use in youth and covid 19 versus influenza and more. Part two is a look at research related to pollution and the risk of cardiac disease.

Enjoy,

Dr. M

 

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 22

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Mental Health and Sleep for teens and college students, Mother’s Day and a poem about mothers.

Here are some highlights: Teenagers are sleep deprived and have been for decades. Nighttime sleep duration has consistently declined over the past few decades. Peak declinations occurred in the late 1990’s and early 2000’s. Girls were less likely than boys to sleep for 7 hours or more per night….
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast – The Growing Brain and Autism

The Growing Brain and the Upstream Etiologies of Neurodevelopmental disorders – AUTISM
This weeks guest is me! I re-recorded a lecture that I gave in Florida this month at the Annual International Conference for the Institute for Functional Medicine. My goal in this lecture is to look at the upstream reasons that we are seeing more Autism and neurological diversity in children year upon year. It is a wide ranging look at the current state of the science and my thoughts on a unifying theory. As with Dr. Stone’s interview last week with Grow Baby, this is a follow up discussion that is a critical primer for “mother’s to be” regarding disease avoidance measures that can be taken for the best health of the maternal child dyad.
Enjoy,
Dr. M

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