Tag Archives: lipid

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 27

Let us head back to the headwaters of HDL biology to find some more answers. If you did not read the original HDL piece or remember the basics of HDL biology, go back to Newsletter V13 #15 for a review. HDL as an associated biomarker of death risk has a U shaped curve with higher all cause mortality at very low and high levels of volume. Let us understand why? (Madsen et. al. 2017) Anything that causes more LDL, low density lipoproteins, to stay in circulation will raise one’s risk of ASCVD or heart attack. The historical reality (as I have discussed for years) for why we would have these genomic mutations to have more LDL particles in circulation is 1) as a protection mechanism against bacterial infections which were common for thousands of years. The HDL and LDL particles have receptors on their surface to grab bacterial cell wall debris like LTE or LPS and remove them via the liver. This is a massive beneftit to the human species until recent times. 2) as a storage mechanism for calories/recirculation of metabolically expensive cholesterol. (Maile et. al. 2020)(Feng et. al.. 2019)(Trinder et. al. 2021)…….
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 11

This week it is: Cholesterol Lipid Hypothesis Part II

The hypothesis: cholesterol and lipoproteins like LDL are inherently good and necessary unless they become unbalanced either through genetics and most definitely lifestyle choices. From last week: It turns out that the carrier lipoproteins like LDL and HDL cholesterol are an ancient part of our innate immune system that have an important function in fighting infection. We have always used these lipoproteins to clear infectious material before they can do damage…. Plus some research on head trauma as well as the recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 10

This week begins the cholesterol/lipid discussion as it relates to cardiovascular disease. We look at alternative ideas for elevated lipid levels in humans and why this might be so. History and nature had a plan. Could we be the reason for the mismatch of our genes and our health outcomes? We also look at men’s work and some new research on autism spectrum disorders.

Enjoy,

Dr. M