Tag Archives: immunity

Dr. M’s SPA Newsletter Volume 15 Issue 7

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Itaconate, what is it and why does it matter?

Science Heavy – skip to the bold for take home if you want to avoid the science.

The biggest takeaway from this complex science is this: High fat, high sugar diets (Ultra Processed Foods) are associated with decreased itaconate activity and increased inflammation. The science further answers the question of whether we should allow ultra processed food in schools.

Ultra Processed Foods likely reduce itaconate production driving inflammation, metabolic dysregulation, and gut dysbiosis, which could worsen active disease. Lower itaconate levels likely impair your body’s ability to resolve inflammation, potentially leading to prolonged issues with healing and repair. To support itaconate’s anti inflammatory activity, shift away from UPFs toward an anti-inflammatory diet (e.g., Mediterranean, rich in vegetables, omega-3s, and fiber) to reduce inflammation, support gut health, and enhance itaconate’s immune-regulating effects.

Science:…..

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 21

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Excess Weight Gain, Obesity and Immune Related Diseases in 2 cases
I want to share a few recent case experiences that shed light on the patient provider experience in the context of a collaborative clinic model based on prevention and the patient first mentality.
In the struggle against the US based disease onslaught that is excess weight gain, longevity with the patient remains the greatest winner for a quality outcome. What do I mean when I say this? Let me tell you a story. I care for a wonderful young man who is about to turn 17 years old. I have known him since birth and his struggle with weight has been profound for most of these 17 years…… Plus an article review about weight loss and a recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 9

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Light and It’s Impacts on Health – Circadian Rhythms
Circadian comes from the latin Circa Diem or about the day
I have long believed that indoor sedentary behavior is profoundly bad for us beyond just the lack of movement and outdoor natural education. Today, we will look at another major concern: light. We will also get into a circadian rhythm post looking at Dr. Panda’s work. A final addition of a recipe of the week.
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 5

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Sugar, Immune Health and Two Studies
Let us start right out of the gate with two studies. #1: Here is the abstract from European Journal of Clinical Nutrition: “Milk contributes with saturated fat, but randomized controlled trials (RCT) on the effects of dairy on the risk of type 2 diabetes (T2D) where dairy is given as whole foods are scarce. The objective of our study was to investigate the long-term effects of semi-skimmed milk on insulin sensitivity and further to compare milk with sugar-sweetened soft drinks (SSSD). A secondary analysis of a 6-month RCT with 60 overweight and obese subjects randomly assigned to 1 L/d of either milk (1.5 g fat/100 mL), SSSD, non-calorie soft drink (NCSD), or water was conducted. Insulin sensitivity was evaluated by oral glucose tolerance test (OGTT) and plasma free fatty acids. Second, fasting blood lipids, blood pressure, and concentration of plasminogen activator inhibitor-1 were assessed……and more on antibiotic resistance.
Enjoy,
Dr. M

Dr. M’s Women and Children First Podcast #56 – Robert Roundtree, MD – The Autoimmune Story

Robert Roundtree, MD
This weeks guest is Bob Roundtree.
Robert Rountree, MD, received his medical degree from the University of North Carolina School of Medicine at Chapel Hill in 1980 before completing a residency in family and community medicine at Penn State Hershey Medical Center. He augmented his medicine training with extensive postgraduate studies in nutritional and herbal pharmacology along with certification as a master practitioner of neuro-linguistic programming. Dr. Rountree has provided his unique combination of traditional family medicine, nutrition, herbology, and mind-body therapy in Boulder, CO, since 1983. He has recently opened Boulder Wellcare, a private practice specializing in individual healthcare consulting. He is coauthor of three books on integrative medicine,Immunotics: A Revolutionary Way to Fight Infection, Beat Chronic Illness, and Stay Well (Putnam, 2000); Smart Medicine for a Healthier Child (Avery Publishing, 1994); and A Parent’s Guide to Medical Emergencies (Avery, 1997). He is an amazing teacher about all things disease prevention based through a functional medicine lens.
This week we dive into the world of autoimmunity and human health. Why is it happening? How can we stem the tide of immune auto reactivity? What are some treatment options? And so much more….
Enjoy,
Dr. M

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Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 31

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THE NUTRITIONAL STUDIES
We know that the foods that we consume affect our intestinal microbiome, our immune system, our metabolism and therefore have a significant effect on inflammation. Is this knowledge translatable to asthma? Let us look specifically at nutrition as it relates to Asthma. Are there specific diet studies available that lead us toward a unified diet for better asthma health? Can we make good recommendations for our patients on a macronutrient basis with fats, carbohydrates and protein ratios and types. Do we have data to support certain micronutrient needs in asthma and how a diet could provide these nutrients? How much can we trust the data?…..
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 36

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Biome Depletion Theory or Biota Alteration Theory
When we look at risk of disease over time in humans, we need to take stock in what was supposed to be versus what is. If we become mismatched genetically to the environment that we find ourselves in, then we will begin to suffer disease. The work of Dr. William Parker and colleagues is very fascinating here. His understanding of our immune solvency takes us back to a time when macrobes like parasites lived with us in a semi-symbiotic way. Most of them were harmless where a few were pathogenic. This matters tremendously because as we are learning, the microbes that exist within us play a major role in tuning the immune system towards tolerance and effective pathogen killing.
A lot to explore here,
Dr. M

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