Tag Archives: health

Dr. M’s SPA Newsletter Volume 16 Issue 12 – Creatine and Microbiomes


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Creatine and Microbiomes

A new 2026 Cell Metabolism study explores a compelling and increasingly central idea in modern biology: the gut/brain/immune/metabolism axis is not just associative, it is mechanistic. Specifically, Dr. Lu and colleagues investigate how the gut microbiota can directly influence depressive behavior by reshaping systemic and neural metabolism. This is another in a long running list of papers describing the amazing work that bacterial commensal microbes do for us. In this case, our minds and moods.

“Although peripheral-brain crosstalk regulates energy metabolism, its role in depression remains unclear. Here, we used metabolic profiling to reveal elevated fecal creatine alongside reduced plasma and cerebrospinal fluid creatine in both patients with depression and mouse depression models. Exogenous creatine produced antidepressant-like effects mediated by gut microbiota. Bifidobacterium pseudolongum was identified as a significantly reduced gut bacterial species in depression, correlating with impaired creatine absorption. Subsequent supplementation with Bifidobacterium enhanced the antidepressant effects of creatine. Mechanistically, B. pseudolongum-derived acetate promoted the creatine transporter (Slc6a8) expression in intestinal epithelial cells via histone acetylation. The Slc6a8 mediated the antidepressant-like effects of creatine. Neuronal creatine deficiency influenced energetic metabolism and neurophysiological function. In patients with depression taking antidepressants, co-administration of creatine and Bifidobacterium increased plasma creatine levels and reduced depression scores. These findings identify the Bifidobacterium-creatine combination as a promising antidepressant strategy and highlight the critical role of gut-brain energy metabolism in depression.” “The brain, as an energy-intensive organ, relies on precise metabolic regulation to maintain synaptic plasticity, neurotransmitter synthesis, and stress response systems. Accumulating evidence implicates energy metabolism dysregulation as a hallmark of depression. Neuroimaging studies using positron emission tomography (PET) have identified marked glucose hypometabolism in the medial prefrontal cortex (mPFC) of patients with depression. Cerebral mitochondrial dysfunction and ATP imbalance have been mechanistically linked to depression progression. Notably, emerging studies emphasize the bidirectional interplay between peripheral metabolic signals and central energy regulation, which is fundamental to neural metabolism. Clinical observations such as fatigue, appetite dysregulation, and unexplained weight fluctuations in patients with depression further suggest systemic metabolic disturbances spanning peripheral organs and the CNS..” (Lu et. al. 2026)

This is next-level medicine. Mental health can no longer be framed as a disorder of genetics, experience, or circumstance alone. This work opens a clearer window, showing how the microbiome participates as an active partner, shaping brain function through the metabolites it helps produce and deliver. Compounds like creatine are no longer just peripheral players. They become signals, fuel, structure, and information, bridging gut and brain, metabolism and behavior…. and more

Enjoy,
Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 9 – Leadership


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Brene Brown – Leadership

Tools to Teach Your Children and SELF

“Stand firmly enough to lead, loosely enough to listen.”

Strong Ground by Brené Brown published in 2025

Breaking down this new book by the excellent Brene Brown, we find that strong leaders don’t eliminate tension or risk. They hold it. And this is key! What does the hold look like? How does it show up to the team?

The theme in my mind is “toughness with tenderness”

Clarity is kindness. Vagueness is avoidance dressed as politeness.
You can be both confident and uncertain. That’s not weakness, it’s reality.
Values are not what you believe. They’re what you do under pressure.
Most leadership failures are emotional avoidance, not strategic failure.
Accountability without empathy is cruelty. Empathy without accountability is chaos.
People don’t disengage because work is hard, they disengage because trust erodes.
The goal is not control. The goal is grounded presence in uncertainty.
You can’t build brave cultures with armored leaders.
Paradox is not a problem to solve, it’s a condition to manage.
If you’re always comfortable, you’re not leading. You’re maintaining.

I especially, like the last one. Discomfort is the path to growth in all things. Think euthermia for temperature, not a recipe for human cellular health or plants for that matter. Temperature through environmental swings are keys to protein elaboration for handling the cold and the heat. The lack of swing equates to a lack of adaptability…. and a piece on the Stakeholder.

Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 8 – Systems Biology


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THE FUNCTIONAL MEDICINE STORY
DR. JEFF BLAND

“Change occurs from the outside in”
Dr. Bland

Medicine has a habit of believing it has arrived. Every generation of physicians looks around the room, surveys the white coats and microscopes and MRI machines, and quietly assumes the puzzle is mostly solved. History laughs at that assumption. The truth is that medicine is always mid-sentence in a very long story.

Dr. Jeff Bland has spent decades helping rewrite that sentence.

In a recent conversation on The Root Cause Business of Medicine Podcast, Dr. Bland’s life work comes into focus. Not as a rebellion against medicine, but as an expansion of it. His influence on nutrition science, biochemical individuality, and what we now call functional medicine has helped move the field away from the narrow idea that disease is simply something to suppress or worse just name. Instead, he has pushed a more interesting question forward: why did the disease appear in the first place?

That sounds obvious. It is so far from obvious that most physicians do not ask the question.

Bland’s career sits at the intersection of nutrition, biochemistry, genetics, and what he calls systems biology. Over the decades he has authored more than 100 peer-reviewed papers and written many books aimed at both clinicians and the public. But numbers don’t tell the story. What matters is the conceptual shift he helped introduce.

For most of modern medical history, the dominant model has been reductionist. And reductionism is the scientific approach of breaking complex systems into their smallest parts. It has given us antibiotics, vaccines, and surgical techniques that save lives every day. But it has also left a blind spot. When we zoom too far in, we sometimes lose the map of the entire ecosystem.

Human biology is not a machine made of replaceable parts. It is a network.

It is supremely interconnected…. and a literature review
Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 4 – Relationships

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Literature Review:

A) “Establishment of the gut microbiome during early life is a complex process with lasting implications for an individual’s health. Several factors influence microbial assembly; however, breast-feeding is recognized as one of the most influential drivers of gut microbiome composition during infancy, with potential implications for function. Differences in gut microbial communities between breast-fed and formula-fed infants have been consistently observed and are hypothesized to partially mediate the relationships between breast-feeding and decreased risk for numerous communicable and noncommunicable diseases in early life. Despite decades of research on the gut microbiome of breast-fed infants, there are large scientific gaps in understanding how human milk has evolved to support microbial and immune development.” (Davis et. al. 2022)

Main Takeaways:

First 1000 days matter a lot for microbial and immune development: Infancy is a critical window when the gut microbiome is assembled and the immune system is learning to respond to microbes and external exposures. Patterns set early can ripple into infection risk, inflammatory diseases, and atopy later in life.

Enjoy,
Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 2 – School Food

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School Based Nutrition – Why is it happening this way?

There is a quiet experiment happening in American childhood, and we should stop pretending it’s benign.

In the 1970s and 1980s, when I attended school, school food was far from perfect, but it existed in the context of something essential: it was mostly prepared on site, minimally processed (but changing in that direction) and not laden with additives and chemicals (Yet). Oh, and most children still ate meals prepared at home at almost every other occasion. Dinner wasn’t aspirational or Instagram-worthy, but it was routine. Real food. Cooked by someone who knew the child, at a table where nervous systems could downshift. School lunch was a supplement to that structure, not the metabolic foundation of a child’s life. That has all changed in a short 50 years. Mirroring the change in weight and childhood disease prevalence.

• 1970s – some processed foods begin to enter school cafeterias at scale
• 1980s – preservatives and additives become routine
• 1990s – ultra-processed foods dominate

In 1994, new standards were added: This table lays out how much of each food group schools were supposed to offer over a week under the 1994 standards. These were the first nutrition-focused meal standards the USDA put into place:

For Breakfast (all grades K–12):
Fruit: 2.5 cups/week
Vegetables: 0 cups/week
Grains/Bread: 0–10 oz equivalent/week (depending on combinations of grains and protein)
Meat/Meat-alternative: 0–10 oz equivalent/week
Milk: 5 cups/week

For Lunch (split by grade levels):
Fruit: K–3 also 2.5 cups; grades 4–12 get 3.75 cups/week
Vegetables: still 0 cups/week (no separate vegetable requirement yet)
Grains/Bread: at least 8 oz eq/week
Meat/Meat-alternative: 7.5 oz eq/week for breakfast; 10 oz eq/week for lunch
Milk: 5 cups/week

(Hopkins 2015)

What’s notable, reflected in the structure of this table, is that vegetables weren’t required at all yet, and the standards were very much food-group based, not ingredient-level nutrient quality checks. That created space for schools to rely on industrially produced entrées and sides that technically met volumes of grains or proteins but could still be ultra-processed products with long ingredient lists, many of these foods would meet a NOVA class 4 classification (the worst type). Think fruit cup in sugary syrup…..

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 28 – Feeding Infants


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Food in Infancy
What do we know?

“Humans are the only mammals who feed our young special complementary foods before weaning and we are the only primates that wean our young before they can forage independently. There appears to be a sensitive period in the first several months of life when infants readily accept a wide variety of tastes and this period overlaps with a critical window for oral tolerance. As a result, infants should be exposed to a wide variety of flavors while mother is pregnant, while mother is nursing and beginning at an early age. There also appears to be a sensitive period between 4 and 9 months when infants are most receptive to different food textures. There remains debate about when it is best to begin introducing solid foods into an infant’s diet however, the available evidence suggests that provided the water and food supply are free of contamination, and the infant is provided adequate nutrition, there are no clear contraindications to feeding infants complementary foods at any age. There is emerging evidence that introduction of solid foods into an infant’s diet by 4 months may increase their willingness to eat a variety of fruits and vegetables later in life, decrease their risk of having feeding problems later in life, and decrease their risk of developing food allergies, and the early introduction of solid foods into an infant’s diet does not appear to increase their risk of obesity later in childhood.” (Borowitz S. 2021)

Food Introductions — What’s the best way to approach it?

As infants begin the shift from exclusive milk feeding to solid foods, a range of opinions inevitably emerge on how to navigate that transition. It’s tempting to get lost in modern guidelines, but an anthropological lens is often more revealing. Long before the age of purées in jars and puffed snacks in canisters, human infants ate what their parents ate. It was delivered in whole-food form and mechanically softened by chewing, cooking, or crushing. These early first foods carried important evolutionary advantages…Plus a piece on Hell Yeh or No by Derek Sivers

Enjoy,
Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 27 – Immune Aging

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The Evolutionary Tug-of-War – Inflammation’s Double-Edged Sword

“Environmental factors, particularly infections, have fundamentally shaped human evolution by selecting for protective inflammatory response mechanisms that enhance survival. This evolutionary pressure has created a core biological paradox: inflammation is indispensable for host defense, yet its dysregulation significantly heightens disease and mortality risk. This fundamental tension raises three fundamental questions about human aging and immunity: (1) How have selective pressures driven the evolution of mechanisms to balance inflammation’s protective benefits against its harmful consequences? (2) Why does substantial variability in healthspan persist despite historically stable rates of aging? (3) Does evolutionary prioritization of reproductive fitness inherently limit longevity?” (Manoharan et. al. 2025)

Let’s talk about the fire inside us. Inflammation is our body’s 911 system: lightning-fast, life-saving when a bug invades or a thorn rips skin. But leave that alarm blaring 24/7 and the fire torches the house.

Evolution faced this paradox: crank the immune dial high enough to survive infection and childbirth, yet install brakes so we don’t self-destruct by 40. Manoharan’s team just mapped those brakes in 17,500 humans and called it immune resilience (IR) or the ability to fight hard, clean up fast, and stay cool afterward… and linguistic aging associations…

Dr. M

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