neurology

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 4

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This week we do a literature review looking at Neurology with specific stops at sleep loss and emotional regulation, APOE4 and Alzheimer’s Disease, memory consolidation with sleep versus wake, gaslighting and more . We also look at potassium as a mineral of necessity. We finish with obesity and Semaglutide.   Enjoy, Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 1

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Covid update #77 with quick hits on vaccines in young adults, POTS or hypotension following Covid 19 as well as obesity and Sars2. Non covid research looking at the brain.

From Nature Communications: “Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from start to end… Here we show that over 30% of species, genes and pathways tested have altered abundances in PD, depicting a widespread dysbiosis.”

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 50

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The fundamentals are these: Age related changes that lead to neuronal loss and cognitive decline are related to loss or reduction of myokine release, systemic inflammation, insulin resistance, reactive oxygen induced mitochondrial stress, DNA mutations and poor protein intake.
First, exercise releases chemicals called myokines which are cell signaling molecules that have the job of telling other cells what to do via changes in gene expression, protein transcription and much more. The prototypical change is the increase of a substance called brain derived neurotrophic factor, BDNF, for short. BDNF is critical for brain cell mitochondrial biogenesis. BDNF promotes many developmental functions in the brain, including neuronal cell survival, differentiation, migration, dendritic arborization, and synaptic plasticity. Regular exercise promotes a progressive increase in BDNF protein for up to at least 3 mo………
Enjoy,
Dr.M