nutrition

Dr. M’s SPA Newsletter Volume 15 Issue 8

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Itaconate, what is it and why does it matter?

Science Heavy – skip to the bold for take home if you want to avoid the science.

The biggest takeaway from this complex science is this: High fat, high sugar diets (Ultra Processed Foods) are associated with decreased itaconate activity and increased inflammation. The science further answers the question of whether we should allow ultra processed food in schools.

Ultra Processed Foods likely reduce itaconate production driving inflammation, metabolic dysregulation, and gut dysbiosis, which could worsen active disease. Lower itaconate levels likely impair your body’s ability to resolve inflammation, potentially leading to prolonged issues with healing and repair. To support itaconate’s anti inflammatory activity, shift away from UPFs toward an anti-inflammatory diet (e.g., Mediterranean, rich in vegetables, omega-3s, and fiber) to reduce inflammation, support gut health, and enhance itaconate’s immune-regulating effects.

Science:…..

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #90 – Kevin Boyd, DDS – Sugar, Oxygen and Neonatal Development

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Welcome to Dr. M’s Women and Children First Podcast, where we explore groundbreaking approaches to health and wellness for women and children. Today, we’re honored to introduce Dr. Kevin Boyd, DDS, MSc, a board-certified pediatric dentist and a trailblazer in the field of evolutionary oral medicine. With an illustrious career spanning over three decades, Dr. Boyd practices in Chicago and serves as an attending instructor at Lurie Children’s Hospital’s Pediatric Dentistry Residency Program, where he also consults for the Sleep Medicine service.

Dr. Boyd’s unique perspective is rooted in his undergraduate work in Biological Anthropology at Northeastern University as well as a Masters of science in Human Nutrition and Dietetics from Michigan State University.

As a Visiting Scholar at the University of Pennsylvania’s Museum of Anthropology, he conducts pioneering research into how dietary and lifestyle changes since the Industrial Revolution have impacted craniofacial and respiratory development. His work in Darwinian Dentistry draws on anthropological insights, examining prehistoric fossil records to understand modern systemic diseases, particularly those affecting airway health in children.

A passionate advocate for early intervention, Dr. Boyd focuses on preventing and treating craniofacial-respiratory issues in young children, often under age 7, to promote healthy breathing, sleep, and neurocognitive development. Through his global lectures on early childhood malocclusion, pediatric sleep-breathing hygiene, and evolutionary oral medicine, Dr. Boyd is educating clinicians and parents alike.

Join us as Dr. Boyd shares his anthropological insights, clinical expertise, and vision for revolutionizing airway health to help women and children thrive. Let’s dive in!

Dr. M

Dr. M’s Women and Children First Podcast #14 Repost- Richard Johnson MD – Nature Wants Us to Be Fat

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This is a repost of the most listened to podcast with Richard J. Johnson, M.D.. Dr. Johnson is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will introduce you to the exceptional work of Dr. Johnson and how we are now mismatched metabolically for the environment of modern America and our food systems.

Please enjoy this wide ranging conversation.

Dr. M

Dr. M’s Women and Children First Podcast #85 – Lily Nichols RD

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Welcome back to Dr. M’s Women and Children First Podcast, where we dive deep into the latest research and expert insights on health, nutrition, and optimizing well-being. Today, we sit down with an influential voice in prenatal and fertility nutrition, Lily Nichols, RD.

Lily is a registered dietitian, researcher, and best-selling author known for her groundbreaking work on real food nutrition for pregnancy. Her previous books, Real Food for Pregnancy and Real Food for Gestational Diabetes, have redefined how we think about maternal nutrition, blending ancestral wisdom with cutting-edge science. Now, with her latest book, Real Food for Fertility, she expands her expertise to help couples optimize their chances of conception and support a healthy pregnancy from the very start.

In this conversation, we’ll explore the critical role of nutrient-dense, whole foods in fertility, how conventional dietary advice may be missing key elements, and why blood sugar balance, gut health, and micronutrient status are essential for reproductive success. Lily’s research-driven approach challenges outdated dogma and offers practical, evidence-based solutions that can make a real impact on fertility outcomes.

Whether you’re planning for pregnancy, supporting a loved one on their journey, or simply interested in how diet shapes reproductive health, this episode is packed with actionable takeaways.

Join me in welcoming Lily Nichols, RD, to the podcast!

Dr. M

Real Food for Fertility

Dr. M’s SPA Newsletter Volume 14 Issue 47

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Sulfurophane and health – It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023)

Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body’s resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

Dr. M’s SPA Newsletter Volume 14 Issue 46

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Lymphatics – Refresher

Lymphatics – a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. By transporting fats , lymph is involved in vitamin movement to tissues and cells for Vitamins A, D, E, K. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease.

“Traditionally considered a passive route for transport of fluid, immune cells, and lipoproteins, lymphatics are now known to be active players in major physiological and pathophysiological processes. Until recently, lymphatic vessel dysfunction was mainly associated with primary and secondary lymphedema. Unexpectedly, however, lymphatic vascular defects have been uncovered in conditions such as obesity, cardiovas- cular disease, inflammation, hypertension, atherosclerosis, Crohn’s disease, glaucoma and various neurological disorders such as Alzheimer’s disease.” (Oliver et. al. 2021)…and a discussion on chemicals in school food.

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #82 – Megan Lyons, DCN, MBA

Megan Lyons, is a distinguished expert in personalized nutrition and wellness, with over a decade of experience in the field. As the founder of The Lyons’ Share Wellness, she has dedicated more than 14,000 hours to one-on-one nutrition consulting, assisting clients with diverse goals such as weight loss, overcoming emotional eating, managing thyroid dysfunction, and reversing prediabetes and cholesterol issues.

Her academic credentials are extensive:

  • Doctorate of Clinical Nutrition from the University of Western States
  • Master of Science in Holistic Nutrition from Hawthorn University
  • Master of Business Administration from the Kellogg School of Management at Northwestern University
  • Undergraduate degree from Harvard University

Megan is double board-certified as a Clinical and Holistic Nutritionist, and she is a graduate of the Institute for Integrative Nutrition.

In 2016, she authored the Amazon Top 10 bestseller, Start Here: 7 Easy, Diet-Free Steps to Achieve Your Ultimate Health and Happiness. Additionally, she hosts the popular podcast Wellness Your Way, where she shares actionable and motivational health information with thousands of listeners each week.

Our goal today is to highlight the realities of women’s health, hormones and breastfeeding.

Enjoy,

Dr. M

The Lyons Share

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