Newsletter

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 31

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THE NUTRITIONAL STUDIES
We know that the foods that we consume affect our intestinal microbiome, our immune system, our metabolism and therefore have a significant effect on inflammation. Is this knowledge translatable to asthma? Let us look specifically at nutrition as it relates to Asthma. Are there specific diet studies available that lead us toward a unified diet for better asthma health? Can we make good recommendations for our patients on a macronutrient basis with fats, carbohydrates and protein ratios and types. Do we have data to support certain micronutrient needs in asthma and how a diet could provide these nutrients? How much can we trust the data?…..
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 30

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Asthma, Allergies and Nutrition – The Story
Here is a long form look at asthma and allergies as I am preparing a lecture on asthma and allergies for a conference in October. I will break it up into a few parts for your consumption.
  • Asthma is now well known to be an inflammatory disease based on the response to anti-inflammatory medications and pathophysiological evidence making it a prime candidate for anti-inflammatory nutritional interventions.
  • The Standard American Diet is filled with pro-inflammatory highly refined and processed foods that are laden with excessive amounts of sugar and unhealthy fats thus promoting inflammatory pathways that exacerbate disease.
  • The genesis of the inflammation is now believed to start in part in the intestinal and pulmonary microbiomes with the loss of immune tolerance. The intestinal microbiome is highly responsive to whole food dietary alterations.
  • Uric acid, a by product of fructose metabolism, is becoming a known driver of inflammasome activation and local tissue inflammation
  • We will discuss in depth the food choices that lower the inflammatory burden, the asthma phenotype and the food immune reactions that exacerbate disease……..

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 29

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Literature Review:
1) Is loneliness tied to an increase in death risk? A new study in Nature says yes to a degree of the pooled effect size of 1.32 for all cause mortality. (Wang et. al. 2023) In effect, that is a very large effect of the variable loneliness on death risk. Why would this be? Many reasons come to mind. The greatest of which is the control that our mind wields on our immune system. If we think in negative and in sad terms over a period of time, the immune system will shift into a pro inflammatory state and weakened pathogen killing which has massive downstream effects on physiology.
2) In an impressive inoculation study in the UK, researchers gave the ancestral strain of SARS2 to test subjects and then followed them for 2 weeks in quarantine……..
Enjoy
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 28

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Outdoor Yard Safety
Yard work season is here and for me, lots of happy times spent outdoors. I remember as a youth earning money mowing lawns. The work was fun and the money was happily accepted. My father was my mower safety coach. Unfortunately, despite good teaching, I still burned myself on the engine by not paying attention to where I was touching. I still spilt gasoline on myself. I still ran over projectile objects in the grass carelessly. Ah, youth….
Have a great day,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 27

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Let us head back to the headwaters of HDL biology to find some more answers. If you did not read the original HDL piece or remember the basics of HDL biology, go back to Newsletter V13 #15 for a review. HDL as an associated biomarker of death risk has a U shaped curve with higher all cause mortality at very low and high levels of volume. Let us understand why? (Madsen et. al. 2017) Anything that causes more LDL, low density lipoproteins, to stay in circulation will raise one’s risk of ASCVD or heart attack. The historical reality (as I have discussed for years) for why we would have these genomic mutations to have more LDL particles in circulation is 1) as a protection mechanism against bacterial infections which were common for thousands of years. The HDL and LDL particles have receptors on their surface to grab bacterial cell wall debris like LTE or LPS and remove them via the liver. This is a massive beneftit to the human species until recent times. 2) as a storage mechanism for calories/recirculation of metabolically expensive cholesterol. (Maile et. al. 2020)(Feng et. al.. 2019)(Trinder et. al. 2021)…….
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 26

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Do you know if you have periodontal disease?
Do your gums bleed? Do your teeth hurt? Do you have red and beefy appearing gums? Do you floss daily? Do you brush two times a day? Do you have sleep apnea?
Why does this matter? Well it turns out that gingival and tooth related disease is highly associated with cardio metabolic diseases. The main reason is that the bacterial microbes in the oral cavity can travel via the bloodstream to places far and wide in the body leading to inflammation and heart disease when the oral cavity is damaged and then manipulated. This especially occurs during tooth decay and periodontal decay phases of oral disease. There are also associations with autoimmune diseases making your oral health very important…..
Enjoy,
Dr. M

Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 25

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This week we talk all about sweat and heat liberation.

Sweating is a very important tool that the human body and most mammals use to eliminate unwanted stuff. In this case, the body primarily is eliminating heat and toxins via liquid sweat.
When we exercise vigorously or it is a hot day or we find ourselves overheating while fighting an infection, sweat will pour from our skin through glands and an endothermic reaction. The water that is released caries heat from the body with it. It evaporates into the air liberating the heat and thus cooling the body.
In this sweated liquid are electrolytes and toxins. Primarily, the sweat fluid has a natural release of small amounts of sodium and to an even lesser extent, potassium and calcium. This fluid will also facilitate the release of chemicals that the body does not like….. plus a few articles in a literature review.
Enjoy,
Dr. M

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