metabolic disease

Dr. M’s SPA Newsletter Volume 15 Issue 15

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Systemic Maternal Inflammation and Neurodevelopment: The Role of IL-6 and IFN-γ in Autism Spectrum Disorder

I just returned from Estes Park, Colorado where I presented a lecture on the Growing Brain/Mind – a tour through the underpinnings of childhood neurological changes that we call Autism. The timing is perfect for this article to be written.

In an era when chronic disease in children is rising at an unprecedented pace, the search for root causes must include an honest inquiry into the conditions present during fetal development. The review article by Majerczyk and colleagues, Systemic Maternal Inflammation Promotes ASD via IL-6 and IFN-γ, brings forward a critical piece in this puzzle that I began to explore a few years ago when writing a book. It connects the dots between maternal immune dysregulation and long-term neurodevelopmental outcomes, specifically autism spectrum disorder (ASD). Through a synthesis of clinical data and animal research, the authors make a compelling case for the centrality of two inflammatory messengers, interleukin-6 (IL-6) and interferon-gamma (IFN-γ), in shaping fetal brain development during gestational stress. The key words here being GESTATIONAL STRESS, the recurring scientific theme for ASD development, not vaccines… and some literature reviews.

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 8

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Itaconate, what is it and why does it matter?

Science Heavy – skip to the bold for take home if you want to avoid the science.

The biggest takeaway from this complex science is this: High fat, high sugar diets (Ultra Processed Foods) are associated with decreased itaconate activity and increased inflammation. The science further answers the question of whether we should allow ultra processed food in schools.

Ultra Processed Foods likely reduce itaconate production driving inflammation, metabolic dysregulation, and gut dysbiosis, which could worsen active disease. Lower itaconate levels likely impair your body’s ability to resolve inflammation, potentially leading to prolonged issues with healing and repair. To support itaconate’s anti inflammatory activity, shift away from UPFs toward an anti-inflammatory diet (e.g., Mediterranean, rich in vegetables, omega-3s, and fiber) to reduce inflammation, support gut health, and enhance itaconate’s immune-regulating effects.

Science:…..

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 1

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Some Key Literature Review Studies from Year 14

This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward.

1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease…..Plus a to do list and recipe of the week.

Dr. M

Dr. M’s Women and Children First Podcast #14 Repost- Richard Johnson MD – Nature Wants Us to Be Fat

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

This is a repost of the most listened to podcast with Richard J. Johnson, M.D.. Dr. Johnson is the Tomas Berl Professor of Medicine and the Chief of the Renal Division and Hypertension at the University of Colorado since 2008. A graduate of the University of Wisconsin, Madison, with a major in Anthropology, and a graduate of the University of Minnesota Medical School, Minneapolis, he is a physician and nephrologist whose research has focused on the role of sugar, and especially fructose, in driving obesity, diabetes, high blood pressure and kidney disease. Much of this work has explored the role of fructose metabolism, especially the generation of uric acid, in driving this phenotype, and his work has included studies ranging from molecular biology, integrative physiology, and evolutionary biology. He is the author of The Sugar Fix which introduced the first low fructose diet, and also The Fat Switch which explores the role of fructose in driving the obesity epidemic. His newest book, Nature Wants Us To Be Fat, is a tour de force of the entire pathway of survival via metabolic events in the body related to fructose and the polyol pathway. This is a must read book. This podcast will introduce you to the exceptional work of Dr. Johnson and how we are now mismatched metabolically for the environment of modern America and our food systems.

Please enjoy this wide ranging conversation.

Dr. M

Dr. M’s Women and Children First Podcast #85 – Lily Nichols RD

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Welcome back to Dr. M’s Women and Children First Podcast, where we dive deep into the latest research and expert insights on health, nutrition, and optimizing well-being. Today, we sit down with an influential voice in prenatal and fertility nutrition, Lily Nichols, RD.

Lily is a registered dietitian, researcher, and best-selling author known for her groundbreaking work on real food nutrition for pregnancy. Her previous books, Real Food for Pregnancy and Real Food for Gestational Diabetes, have redefined how we think about maternal nutrition, blending ancestral wisdom with cutting-edge science. Now, with her latest book, Real Food for Fertility, she expands her expertise to help couples optimize their chances of conception and support a healthy pregnancy from the very start.

In this conversation, we’ll explore the critical role of nutrient-dense, whole foods in fertility, how conventional dietary advice may be missing key elements, and why blood sugar balance, gut health, and micronutrient status are essential for reproductive success. Lily’s research-driven approach challenges outdated dogma and offers practical, evidence-based solutions that can make a real impact on fertility outcomes.

Whether you’re planning for pregnancy, supporting a loved one on their journey, or simply interested in how diet shapes reproductive health, this episode is packed with actionable takeaways.

Join me in welcoming Lily Nichols, RD, to the podcast!

Dr. M

Real Food for Fertility

Dr. M’s SPA Newsletter Volume 14 Issue 46

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Lymphatics – Refresher

Lymphatics – a plumbing system that follows the circulatory system throughout the body including the brain where it is called the glymphatics. The function of these passively moving tubes is to transport fats around the body, clear cellular debris returning it to the liver and spleen, move fluid in and out of tissue to maintain fluid balance, transport and help immune cells function. By transporting fats , lymph is involved in vitamin movement to tissues and cells for Vitamins A, D, E, K. These are critical functions of metabolism, immunity and detoxification that when disrupted lead to chronic diseases of aging including edema, hypertension, autoimmunity and cardiovascular disease.

“Traditionally considered a passive route for transport of fluid, immune cells, and lipoproteins, lymphatics are now known to be active players in major physiological and pathophysiological processes. Until recently, lymphatic vessel dysfunction was mainly associated with primary and secondary lymphedema. Unexpectedly, however, lymphatic vascular defects have been uncovered in conditions such as obesity, cardiovas- cular disease, inflammation, hypertension, atherosclerosis, Crohn’s disease, glaucoma and various neurological disorders such as Alzheimer’s disease.” (Oliver et. al. 2021)…and a discussion on chemicals in school food.

Enjoy,

Dr. M

Dr. M’s Women and Children First Podcast #82 – Megan Lyons, DCN, MBA

Megan Lyons, is a distinguished expert in personalized nutrition and wellness, with over a decade of experience in the field. As the founder of The Lyons’ Share Wellness, she has dedicated more than 14,000 hours to one-on-one nutrition consulting, assisting clients with diverse goals such as weight loss, overcoming emotional eating, managing thyroid dysfunction, and reversing prediabetes and cholesterol issues.

Her academic credentials are extensive:

  • Doctorate of Clinical Nutrition from the University of Western States
  • Master of Science in Holistic Nutrition from Hawthorn University
  • Master of Business Administration from the Kellogg School of Management at Northwestern University
  • Undergraduate degree from Harvard University

Megan is double board-certified as a Clinical and Holistic Nutritionist, and she is a graduate of the Institute for Integrative Nutrition.

In 2016, she authored the Amazon Top 10 bestseller, Start Here: 7 Easy, Diet-Free Steps to Achieve Your Ultimate Health and Happiness. Additionally, she hosts the popular podcast Wellness Your Way, where she shares actionable and motivational health information with thousands of listeners each week.

Our goal today is to highlight the realities of women’s health, hormones and breastfeeding.

Enjoy,

Dr. M

The Lyons Share

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

1 2 … 8