metabolic

Dr. M’s Women and Children First Podcast #19 Repost – Dr. Alessio Fasano – Intestinal Permeability, Microbiome and MIS

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In this podcast repost, we rediscover the work of Pediatric Gastroenterologist Dr. Alessio Fasano from the Massachusettes General Hospital Department of Pediatric Gastroenterology. In this conversation, we discussed the research on Intestinal Permeability, Microbiomes and MIS, Multi Inflammatory Syndrome in Children .
Dr. Fasano also directs the Mucosal Immunology and Biology Research Center and is associate chief for Basic, Clinical and Translational Research. Under his leadership, investigators are studying the molecular mechanisms of autoimmune disorders including celiac disease, and other-gluten-related disorders. He has been named visiting professor of pediatrics at Harvard Medical School. He authored the groundbreaking study in 2003 that established the rate of celiac disease at one in 133 Americans. Widely sought after by national and international media, Dr. Fasano has been featured in hundreds of interviews including outlets such as The New York Times, The Wall Street Journal; National Public Radio; CNN; Bloomberg News, and others.
He recently co authored an excellent book with Susie Flaherty called Gut Feelings. I highly recommend you purchase and read this book. It is an encyclopedia of information regarding gut health, the microbiome and much more.
Enjoy my conversation with Dr. Fasano,
Dr. M

Dr. M’s SPA Newsletter Volume 16 Issue 18 – Autism and Microbiomes

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Autism and Diagnosis

Metabolites and Phenotypes

In a brand new paper entitled. “Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype,” Dr. Flynn and colleagues investigated whether specific urinary metabolites produced by intestinal microbes could serve as predictive biomarkers for autism spectrum disorder. The study proposes that a large subset of children with autism may represent a biologically distinct phenotype characterized by markedly elevated microbial metabolites, which the authors term ASD-MDM (Autism Spectrum Disorder associated with Microbially-Derived Metabolites).

The investigators analyzed urine samples from 52 children with ASD and 47 typically developing (TD) controls, ages 2–11 years. They measured microbial metabolites derived primarily from phenylalanine metabolism, tryptophan metabolism, and yeast metabolism. These were chosen because decades of autism, microbiome, and metabolic research have repeatedly implicated abnormalities in microbial metabolism of aromatic amino acids, especially phenylalanine and tryptophan, along with evidence of elevated fungal/yeast metabolites in subsets of children with ASD.

The findings were striking. Children with ASD demonstrated significantly higher concentrations of many microbial metabolites than controls. Some metabolites were elevated by hundreds to thousands of percent, and in certain children concentrations were reported to be 100–1000 times higher than the highest levels observed in any control participant. Twenty-three of twenty-four measured microbial metabolites were higher in ASD participants. Ninety percent of the ASD participants (45 of 50) had one or more extremely elevated MDMs. Particularly notable were elevations in compounds related to p-cresol, p-cresol sulfate, phenylacetylglutamine, indole derivatives, and arabinitol, suggesting abnormalities in microbial metabolism involving aromatic amino acids and yeast overgrowth…. Also, Inflammation and Allergy.

Enjoy,
Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 25 – Tough Conversations

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Speaking Truth in Love: The Weight of Avoidance in Pediatric Metabolic Health

After completing the second round of our Asthma and Obesity Metabolic Pilot Program at Salisbury Pediatrics, I left the clinic reflecting deeply on what I witnessed. It crystallized a truth that is uncomfortable but undeniable: the greatest health threats to our children today are not infectious or accidental, they are metabolic. Diseases once reserved for adulthood: insulin resistance, fatty liver, hypertension, early vascular aging are now appearing in children who should be free to run, play, and thrive.

In modern society, conversations about weight and metabolic dysfunction have become relatively taboo. This is not to say that children of normal or low weight are immune; they, too, can be at risk. However, the excess-weight group carries the highest statistical burden. Too often, clinicians hesitate to speak truth to families for fear of offending, shaming, or overstepping. In doing so, we risk silence becoming complicity and allowing preventable disease to take root in the very children we are charged to protect.

Much of this epidemic is not born of individual failure but of systemic neglect. Government-funded, poor-quality school meals, cheap processed foods, and relentless marketing of sugar and refined carbohydrates have built an environment where metabolic injury is almost inevitable. When a child’s daily fuel is engineered for shelf life instead of cell life, the outcome is not accidental, it is predictable. Our pilot program lab results are a painful window into that truth…. and a literature review on eczema and anaphylaxis.

Enjoy Dr. M

Dr. M’s Women and Children First Podcast #99 Liz Mumper, MD – Kids and Covid

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Welcome to Dr. M’s Women & Children First Podcast, where we engage with pioneering voices at the intersection of science, healthcare, and the well-being of families.

Today on Dr. M’s Women and Children First, we welcome Dr. Elizabeth Mumper, a physician, educator, and thought leader whose career has profoundly influenced the practice of integrative pediatrics.

Dr. Mumper earned her Bachelor of Science degree from Bridgewater College, graduating magna cum laude, before attending the Virginia Commonwealth University School of Medicine, where she received her medical degree. She completed her pediatric residency at the University of Virginia and served as Chief Resident in Pediatrics. She remained at UVA as an Associate Professor of Clinical Pediatrics from 1997 to 2005, mentoring future physicians and advancing holistic, evidence-based approaches to child health.

Following her time in academia, Dr. Mumper founded The Rimland Center for Integrative Medicine in Lynchburg, Virginia, a clinic dedicated to children with autism spectrum disorders, PANS/PANDAS, allergies, and complex chronic illnesses. Her practice integrates the best of conventional pediatrics with biomedical and functional medicine principles, always guided by compassion and curiosity.

She has been a leading educator with the Medical Academy of Pediatric Special Needs (MAPS) and a frequent international lecturer, teaching clinicians how to recognize and treat the root causes of immune dysregulation, inflammation, and neurodevelopmental challenges.

Dr. Mumper is also the author of the new book Kids and COVID, an insightful exploration of how the pandemic impacted children, physically, emotionally, and developmentally, and what lessons medicine must learn moving forward. In our conversation, we discuss her book in depth, as well as the broader implications of the COVID-19 pandemic for pediatric care, resilience, and future public health policy.

Finally, we dive into the complex topic of vaccines, considering what we’ve learned from the pandemic years and expanding the conversation begun with Dr. Paul Offit and Dr. Joel Warsh.

Dr. Mumper’s lifelong dedication to children, her fearless pursuit of truth, and her balanced, science-driven voice make her one of the most respected figures in functional medicine.

Please join me in welcoming my friend and colleague,  Dr. Elizabeth Mumper.

Dr. M

Dr. M’s Women and Children First Podcast #90 – Kevin Boyd, DDS – Sugar, Oxygen and Neonatal Development

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Welcome to Dr. M’s Women and Children First Podcast, where we explore groundbreaking approaches to health and wellness for women and children. Today, we’re honored to introduce Dr. Kevin Boyd, DDS, MSc, a board-certified pediatric dentist and a trailblazer in the field of evolutionary oral medicine. With an illustrious career spanning over three decades, Dr. Boyd practices in Chicago and serves as an attending instructor at Lurie Children’s Hospital’s Pediatric Dentistry Residency Program, where he also consults for the Sleep Medicine service.

Dr. Boyd’s unique perspective is rooted in his undergraduate work in Biological Anthropology at Northeastern University as well as a Masters of science in Human Nutrition and Dietetics from Michigan State University.

As a Visiting Scholar at the University of Pennsylvania’s Museum of Anthropology, he conducts pioneering research into how dietary and lifestyle changes since the Industrial Revolution have impacted craniofacial and respiratory development. His work in Darwinian Dentistry draws on anthropological insights, examining prehistoric fossil records to understand modern systemic diseases, particularly those affecting airway health in children.

A passionate advocate for early intervention, Dr. Boyd focuses on preventing and treating craniofacial-respiratory issues in young children, often under age 7, to promote healthy breathing, sleep, and neurocognitive development. Through his global lectures on early childhood malocclusion, pediatric sleep-breathing hygiene, and evolutionary oral medicine, Dr. Boyd is educating clinicians and parents alike.

Join us as Dr. Boyd shares his anthropological insights, clinical expertise, and vision for revolutionizing airway health to help women and children thrive. Let’s dive in!

Dr. M

Dr. M’s Women and Children First Podcast #88 – Michael Collins – Sugar Addiction

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Today we’re tackling a topic that hits close to home for so many of us, sugar addiction and its impact on our kids and ourselves.

We’ve got an incredible guest joining us: Michael Collins, the author of The Last Resort Sugar Detox Guide: Learn How To Quickly and Easily Detox from Sugar and Stop Cravings Completely. Michael is a former sugar addict who’s been sugar-free for over 30 years, and he’s helped thousands break free from sugar’s grip through his work as the founder of SugarAddiction.com. He’s also raised two children sugar-free from the womb to age six—a feat that’s as inspiring as it is eye-opening. In this episode, Michael will share his journey, the science behind sugar’s addictive pull, and practical strategies to detox for good, especially for families navigating the modern food landscape. Whether you’re a parent worried about your child’s sugar intake or someone struggling with cravings yourself, you won’t want to miss this.

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 1

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Some Key Literature Review Studies from Year 14

This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward.

1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease…..Plus a to do list and recipe of the week.

Dr. M

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