Behavior

Dr. M’s SPA Newsletter Volume 15 Issue 15

August 15, 2025
Dr. M
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asd, autism, cytokine, immunity, maternal immune activation, neurology, obgyn, Pediatrics, prevention

Systemic Maternal Inflammation and Neurodevelopment: The Role of IL-6 and IFN-γ in Autism Spectrum Disorder

I just returned from Estes Park, Colorado where I presented a lecture on the Growing Brain/Mind – a tour through the underpinnings of childhood neurological changes that we call Autism. The timing is perfect for this article to be written.

In an era when chronic disease in children is rising at an unprecedented pace, the search for root causes must include an honest inquiry into the conditions present during fetal development. The review article by Majerczyk and colleagues, Systemic Maternal Inflammation Promotes ASD via IL-6 and IFN-γ, brings forward a critical piece in this puzzle that I began to explore a few years ago when writing a book. It connects the dots between maternal immune dysregulation and long-term neurodevelopmental outcomes, specifically autism spectrum disorder (ASD). Through a synthesis of clinical data and animal research, the authors make a compelling case for the centrality of two inflammatory messengers, interleukin-6 (IL-6) and interferon-gamma (IFN-γ), in shaping fetal brain development during gestational stress. The key words here being GESTATIONAL STRESS, the recurring scientific theme for ASD development, not vaccines… and some literature reviews.

Dr. M

Dr. M’s Women and Children First Podcast #89 – Trenna Sutcliffe, MD – Autism and Development

April 27, 2025
Dr. M
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asd, autism, behavior, clinic, development, Dr. Sutcliffe, parenting, pdd, Pediatrics, stanford, whole child care

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Today we are joined by a remarkable guest, Dr. Trenna Sutcliffe, a board-certified developmental-behavioral pediatrician and the founder of the Sutcliffe Clinic in the San Francisco Bay Area. Her educational history is impressive. She completed her undergraduate education in Molecular Biology and Medical Genetics followed by a masters degree in Biophysics at The University of Toronto. She obtained her Medical degree at McMaster University before her pediatric residency and training finished at the Hospital for Sick Children in Toronto. And oh by the way, she then did a year of pediatric Neurology residency and a Fellowship in Developmental Pediatrics. And finally, another Masters degree in Epidemiology at Stanford University. Thus, her educational path has allowed her to see the developmental landscape through a wider lens covering many disciplines. Dr. Sutcliffe started the first Developmental Pediatrics Clinic at Stanford and played the role of trailblazer throughout her career.

With over 25 years of experience, Dr. Sutcliffe specializes in supporting children with autism, ADHD, and anxiety, offering a multidisciplinary approach to diagnosis and treatment. In this episode, she’ll share her insights on the rising prevalence of these conditions, the importance of personalized care, and practical strategies for parents navigating developmental challenge. Fundamentally, Dr. Sutcliffe is a going to educate us on a better way to deliver whole person care to the developmentally challenged and beautiful children of this country.

Two words encapsulate her work: empowering and thoughtful.

Let’s dive into this conversation with Dr. Sutcliffe to learn how we can help our children thrive!

Dr. M