literature review

Dr. M’s SPA Newsletter Volume 15 Issue 3

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Literature Review

1) Microplastics in the Brain – From Science Advances: “Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting the regular physiological processes of organs. Nanoscale plastics can breach the blood-brain barrier, leading to neurotoxic effects. How MPs cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques to investigate the MPs within the brain in vivo. We show that circulating MPs are phagocytosed and lead these cells to obstruction in the capillaries of the brain cortex. These blockages as thrombus formation cause reduced blood flow and neurological abnormalities in mice. Our data reveal a mechanism by which MPs disrupt tissue function indirectly through regulation of cell obstruction and interference with local blood circulation, rather than direct tissue penetration. This revelation offers a lens through which to comprehend the toxicological implications of MPs that invade the bloodstream.” (Huang et. al. 2025)

This weeks podcast is a direct look at the world of toxicology and the human consequences of exposure over time. Microplastics are the new and next trouble maker on the planet. This study raises the concern that micro and nano plastics can and do enter the brain and will disrupt and thus alter brain physiological processes. More time to answer the true risk reality. Not good. and more….Plus a letter about MAHA from Dr. Jeffrey Bland, a serious take on preventative medicine as opposed to disease pharmaceutical centric medicine.

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 2

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Klotho Protein and Longevity

I am reposting this information from last year because it is going to stay on my mind and I would like everyone to be aware of this peptide and the future of healing and what we can do now to be healthy. The science here is one part fascinating, one part complicated and equal parts necessary.

Ok, it is time for a potential log step shift in the human understanding of neurological decline with age starting from birth.

Enter the peptide, (C)Klotho, named after the greek goddess of fate who spins the thread of life for all. The Klotho protein was discovered by researchers looking at mice that aged faster than the general mouse population. These mice were noted to have a shortened lifespan, stunted growth, renal disease, blood vessel calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. (Prud’homme et. al. 2022) When they looked closer, these mice were found to have hypoactive klotho proteins leading to an explosion of research over the past two decades to understand why. The next question was, could the hyperactive state provide an anti aging effect? To be clear the word anti aging should really say delayed inevitable aging.

The answer was a resounding yes!…..

Dr. M

Dr. M’s SPA Newsletter Volume 15 Issue 1

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Some Key Literature Review Studies from Year 14

This is a bit of a long newsletter. That is intentional. This will be a repository for some of the best research for us to look back on from time to time this coming year to solidify the learning moving forward.

1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease…..Plus a to do list and recipe of the week.

Dr. M

Dr. M’s SPA Newsletter Volume 14 Issue 51

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Here is an article that I wrote for Rupa Fullscript in order to lay the ground work for effective preventative medicine. In order to get a longer runway to preventing disease, targeted lab screening is becoming very important.

Classical medical training often relies on a traditional, binary approach to patient care: either a disease is present, or it is not. Functional medicine builds on this perspective by examining a continuum of potential dysfunction within lab results. Rather than waiting for a definitive diagnosis, functional medicine practitioners look for subtle “breadcrumbs” in the data—early indicators that might signal an evolving health issue long before it fully manifests. Routine lab panels remain a foundational tool, but their deeper insights are frequently underutilized. In functional medicine, we dig into each lab marker more thoroughly, considering it a potential clue to underlying imbalances, nutrient deficiencies, or early disease processes. This more granular interpretation goes beyond the standard understanding of “normal” values, seeking patterns that can inform more personalized and preventive care.

By viewing “normal” lab ranges through a more nuanced lens, functional medicine aims to identify previously overlooked indicators. The ultimate goal is to narrow our concept of “optimal” health ranges, enabling a more attentive and individualized approach that supports the patient’s best possible health outcomes…..plus a section on literature reviews.

Dr. M

Dr. M’s SPA Newsletter Volume 14 Issue 48

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Holidays and Connection

The Christmas and winter holiday season is a unique time to sit back reflect on the past year. To behold the timeless beauty of life. The shared time offers us an opportunity to pause and connect with those who matter or should matter most in our lives. I love the bathroom plaque that says at the end of life it won’t matter what you owned or what you knew, but rather the impact you had in a child’s life. Fortunately, for us, the holidays bring a chance to foster authentic human connections. To actually sit in conspiracy together. These moments are more than just traditions, they are essential for our emotional, mental, and even physical health. In the hustle of modern existence, where schedules dominate and technology often mediates relationships, we are losing this skill set, especially for the younger generations, making it more important to stay focused now.

Let us define human connection: Human connection is the act or feeling of being seen, heard, cared for and valued by another person or group. It is a most primary need for humans starting in infancy when a child needs a mother’s touch and milk. It arises from the countless meaningful interactions that foster mutual understanding, trust, empathy, and shared emotional experiences that ultimately lead to a child’s feeling of safety. The critical time period to establish attachment and connection is the first 2 to 3 years of life. Plus a section of literature review and a recipe of the week.

Enjoy,

Dr. M

Dr. M’s SPA Newsletter Volume 14 Issue 47

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Sulfurophane and health – It is clear now that SFN stands out as a powerhouse phytochemical with profound effects on human health through the pathway of nurclear factor erythroid related 2 (NRF2). It is found abundantly in cruciferous vegetables such as broccoli, broccolini, kale, and brussels sprouts. SFN is a bioactive compound with impressive clinical potential for preventing chronic disease and optimizing cellular health, especially in oxidant impaired/overloaded states. At its core, SFN is a sulfur-rich molecule derived from glucoraphanin, a glucosinolate precursor. The transformation occurs when the enzyme myrosinase, released during the chopping or chewing of cruciferous vegetables, catalyzes the reaction. Interestingly, this enzymatic activation can also be achieved via gut microbiota when raw vegetables are absent from the diet, emphasizing the remarkable adaptability of our biology to source essential nutrients as needed for survival. (Ali et. al. 2023)

Nrf2 is a master regulator of cellular defense, orchestrating the production of detoxification enzymes, antioxidants, and other cytoprotective proteins. By activating Nrf2, sulforaphane enhances the body’s resilience to oxidative stress, a key contributor to aging, inflammation, and the development of chronic diseases such as cardiovascular disease and diabetes. Studies reveal that sulforaphane also induces Phase II detoxification enzymes, such as glutathione S-transferase, which play a vital role in neutralizing and excreting harmful toxins.

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 45

Podcast: Play in new window | Download

Subscribe: Email | RSS | More

Vaccines

In the coming months, I am going to take a deeper look at vaccines. I am fielding lots of questions in the office about the safety of vaccines. People are scared. Are they wrong? Should they be?

Let me start here: first off, I am solidly pro vaccine. That is not the same as to be in agreement with the current vaccine schedule or that vaccines are without risk. I believe that the vaccine schedule and the risk should be questioned on a rolling basis in perpetuetum. This is the function of medical science. Question dogma always. Look for errors of past thinking and reassess on a continual basis.

I think that on the face of it, the skepticism is well placed as the organizations tasked with our safety have made a mess of being honest during the COVID pandemic vaccine rollout….. plus a literature review.

Dr. M

1 2 … 7