Tag Archives: William Parker

Dr. M’s Women and Children First Podcast #98 William Parker, PhD – Acetaminophen and Autism – What Do We Know in 2025?

Welcome to Dr. M’s Women & Children First Podcast, where we engage with pioneering voices at the intersection of science, healthcare, and the well-being of families.

Today, I’m honored to introduce Dr. William Parker, PhD. Dr. Parker is perhaps best known for discovering the function of the human appendix, but his contributions to science extend far beyond that single discovery. He studied biology and chemistry as an undergraduate before earning his PhD in Chemistry from the University of Nebraska–Lincoln in 1992. Since the 1980s, he has conducted innovative research, publishing more than 150 peer-reviewed articles that span immune function, microbiome science, and human health.

Dr. Parker was the first to compare immune systems in wild animals with those of their laboratory counterparts, and among the first to conclude that changes in the human “biota”, the symbiotic organisms living within us, brought on by modern society can contribute to depression and anxiety. After nearly three decades at Duke University, where he served as associate professor and research leader, he founded WPLab, Inc., a nonprofit dedicated to understanding and educating about the causes of chronic inflammatory diseases in high-income societies.

Currently a visiting scholar at the University of North Carolina, Dr. Parker collaborates widely with colleagues from Duke University, University of Montreal, Czech Academy of Sciences, University of Groningen, University of Colorado Boulder, and scientists across the pharmaceutical industry.

In recent years, he has turned his attention to a provocative and urgent question: the potential links between early acetaminophen exposure and autism spectrum outcomes. His current work combines mechanistic and epidemiologic approaches to explore how acetaminophen’s effects on human physiology at critical stages of development might influence neurodevelopment.

In our conversation, we’ll explore:

  • The evidence and hypotheses behind acetaminophen’s potential role in autism risk
  • What families and clinicians should know: what’s plausible, what remains speculative, and where research is heading next

I’m thrilled to share this episode with Dr. Parker, whose intellectual curiosity, scientific rigor, and courage to ask difficult questions embody the spirit of this show.

Dr. M

Dr. M’s Women and Children First Podcast #7 – Dr. William Parker, The “Macrobiome” and Human Health

Dr. William Parker, Associate Professor of Surgery and Global Health at Duke University, will discuss the biome depletion theory and how our cleanliness is disrupting normal immune function. These processes can have profound downstream effects on maternal and child health. From the Duke Medical School: What is widely known as the “hygiene hypothesis” is more appropriately described as the biota alteration or biome depletion theory: Changes in symbiont composition in the ecosystem of the human body in Western culture has led to immune dysfunction and subsequent disease. We are working on several aspects of this theory. Our earlier studies probe the immunological differences between laboratory-raised and wild-raised animals as a means of assessing differences between humans with and without Western culture, respectively. Other studies probe the role of biome enrichment, in particular the addition of helminths, in the treatment of disease. Studies are ongoing in both humans and in animals, with particular attention to the role of biome depletion in cognitive dysfunction.

We discuss the future of human health with a specific focus on our macrobiome friends, parasites, with whom we have co evolved. They are now missing and we are not better off because of it.

 

Please enjoy my conversation with Dr. William Parker,

Dr. M