Disease

Dr. M’s SPA Newsletter Audiocast Volume 12 Issue 50

The fundamentals are these: Age related changes that lead to neuronal loss and cognitive decline are related to loss or reduction of myokine release, systemic inflammation, insulin resistance, reactive oxygen induced mitochondrial stress, DNA mutations and poor protein intake.
First, exercise releases chemicals called myokines which are cell signaling molecules that have the job of telling other cells what to do via changes in gene expression, protein transcription and much more. The prototypical change is the increase of a substance called brain derived neurotrophic factor, BDNF, for short. BDNF is critical for brain cell mitochondrial biogenesis. BDNF promotes many developmental functions in the brain, including neuronal cell survival, differentiation, migration, dendritic arborization, and synaptic plasticity. Regular exercise promotes a progressive increase in BDNF protein for up to at least 3 mo………
Enjoy,
Dr.M

Dr. M’s Women and Children First Podcast #9 – Dr. Tracy Shafizadeh, Evivo Probiotic for Babies

Dr. Tracy Shafizadeh is a nutritional scientist, speaker, and author with over 15 years of experience in scientific communications and life science research. Prior to serving as the Director of Scientific Communications at Evolve BioSystems, she led both product development and research services at various start-up life science companies, including Lipomics Technologies, Tethys Bioscience and Metabolon, Inc. Dr. Shafizadeh received her PhD in nutritional biology from UC Davis, studying intestinal development and folate metabolism in newborns.

Today, we spend the hour discussing the maternal and infant microbiome with respect to maternal breastmilk, human milk sugars and childhood outcome. Evolve Biosystems has produced a probiotic with excellent science to help guide us in new therapeutic discovery. We head to the beginnings of disease onset when the infant is only starting to take his or her first breaths.

I hope that you enjoy my conversation with Dr. Tracy Shafizadeh,

Dr. M

 

Dr. M’s Women and Children First Podcast #4 – Ken Cook, the Environmental Working Group and Your Health

Ken Cook, President and co-founder of the Environmental Working Group, is widely recognized as one of the environmental community’s most prominent and influential critics of industrial agriculture, U.S. food and farm policy and the nation’s broken approach to protecting families and children from toxic substances. Under Cook’s guidance, the organization empowered American families with easy-to-use, data-driven tools to help reduce their exposure to potentially harmful ingredients in foods, drinking water, cosmetics and other household products. These unique digital resources are searched hundreds of millions of times by consumers. 
We discuss the state of the nation with regards to environmental triggers of disease which can cause problems in mothers and children. It is a conversation that every parent needs to hear as it is loaded with news to use for a healthier life.
Please enjoy my conversation with Ken Cook,
Dr. M
Here are two links to the podcast:
Apple Podcasts
Women and Children First
SPA Podcast Page – will be loaded this week

Dr. M’s SPA Newsletter Audiocast Volume 11 Issues 32 and 34

Majestic poplar

Newsletter #32 covers – School and the Covid Generation

More than a year later, as we had feared, we are starting to see and feel the repercussions of the school closure pandemic phenomenon. The K shaped recovery of the economic pandemic is also playing out similarly in the school system. Last year, private schools stayed open while public schools shuttered. Of those in public school systems, many that could afford one, hired tutors to bridge the academic dysfunction of zoom education. The gap between the rich and poor just widened like never before right before our eyes. Regardless of the intent behind the outcome, we are now here. It serves no purpose to blame teachers unions or local governments or parents living in fear or any other publicized reason to date. We are Americans and we must now roll up our sleeves and begin the process of bridging this gap again. These children deserve our total and unwavering support. Link to more….https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/983-school-and-the-covid-generation

Newsletter #34 covers – Long Covid and its association with Epstein Barr Virus, EBV, reactivation

This is a very important topic for clinicians and parents to understand so we are going to look at it a little more deeply.
Long COVID or what appears to be a post infectious inflammatory issue may now be a consequence of another infection. What are the symptoms of long COVID and when do they occur? From the CDC: Some people are experiencing a range of new or ongoing symptoms that can last weeks or months after first being infected with the virus that causes COVID-19. Unlike some of the other types of post-COVID conditions that only tend to occur in people who have had severe illness, these symptoms can happen to anyone who has had COVID-19, even if the illness was mild, or if they had no initial symptoms. Symptoms can even begin weeks after the infection.  Link to more…. https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/990-long-covid-and-its-association-with-epstein-barr-virus-ebv-reactivation

Dr. M’s SPA Newsletter Volume 11 Issue 30

Dental Care – Why is it so important?
We have intermittently discussed dental care over the last 11 years with regard to oral health as well as systemic health. There was an excellent podcast between Dr. Peter Attia and Dr. Patricia Corby two weeks ago looking at all things oral health. I am going to distill the 2 hour podcast down into a manageable audio recording of the newsletter with some more information on dental anthropology and the oral microbiome.
Dr. Corby is an oral health researcher from Penn Dental Medicine in Pennsylvania and she is a wealth of research information in the oral space. Read more here – https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/973-volume-11-letter-30
Have a great day and hug your kids,
Dr. M

Dr. M’s SPA Newsletter Volume 11 Issue 29 Covid Update #39

Coronavirus Update #39 Quick hits
1) Repeat with new information as an important follow up on MIS-C, multi inflammatory syndrome – c., from 2 weeks ago. Remember that in children, MIS-c is associated with poor intestinal function from a microbiome perspective coupled to genetic weaknesses in immune suppression of chemokine CXCL9 post inflammation. Research from the lab of Dr. Alessio Fasano has shown direct evidence of intestinal permeability in children with multi inflammatory syndrome – c:
The authors found that children, unlike adults, the SARS2 virus decides to take up residence in the intestines and replicate there. The virus can be found in the child’s stool via testing. This is a unique finding to children as the intestine is not known to be a harboring site for the virus in adults. The expert researcher on this paper, Dr. Fasano, has extensive knowledge of the function of the intestinal mucosal lining and the fact that the cells are held together by tight junctions made up of different proteins forming a semi impermeable membrane…….
Read more at https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter
Have a great day,
Dr. M

Dr. M’s SPA Newsletter Volume 11 Issue 27 Covid Update #38

Just when you think that the information on SARS2 Covid19 is slowing to a crawl with new discovery, a favorite researcher publishes a truly remarkable bit of scientific discovery. Dr. Alessio Fasano is featured below in Number 6 and his work is really important. A little science heavy but critical for children. There is a take home summary as well. Don’t miss this information.
Quick hits
1) CDC data on adolescent hospitalizations: COVID-19 adolescent hospitalization rates from COVID-NET peaked at 2.1 per 100,000 in early January 2021, declined to 0.6 in mid-March, and rose to 1.3 in April. Among hospitalized adolescents, nearly one third required intensive care unit admission, and 5% required invasive mechanical ventilation; no associated deaths occurred….. Read more at this link: https://www.salisburypediatrics.com/patient-education/dr-magryta-s-newsletter/964-volume-11-letter-27-coronavirus-update-38

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